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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Th17 cells in glaucoma patients promote Ig production in IL IL ‐17A and IL IL ‐21‐dependent manner
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Th17 cells in glaucoma patients promote Ig production in IL IL ‐17A and IL IL ‐21‐dependent manner

机译：青光眼患者中的Th11e细胞促进IG -17A和-21依赖方式的IG生产

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摘要

Summary Elevated expression of autoantibodies is a hallmark of immune dysregulation in glaucoma and may cause retinal ganglion cell apoptosis and immune‐mediated nerve damage, thus contributing to the development of blindness. The cause of autoantibody upregulation remains unclear. Th17 cells are shown to promote autoimmunity and Ig production. Here, we demonstrate that the serum levels of interleukin ( IL )‐17A and IL ‐21 are comparable between glaucoma patients and non‐glaucoma controls. However, the levels of Th17‐promoting cytokines, such as tumour necrosis factor ( TNF) IL ‐6, are higher in glaucoma patients than in controls. Subsequently, we demonstrate that glaucoma patients present upregulated levels of Th17 cells that are quiescent directly ex vivo. Interestingly, compared to the Th17 cells from non‐glaucoma subjects, the Th17 cells from glaucoma patients present similar IL ‐17A production capacity but significantly higher IL ‐21 production capacity. Given that IL ‐21 is also described as a specific cytokine of follicular helper T cells, the Ig production by B cells following co‐incubation with circulating Th17 cells is investigated. Th17 cells from glaucoma patients present significantly enhanced potential to promote Ig production than the Th17 cells from controls. Both glaucoma patient Th17 cells and control Th17 cells require IL ‐17A and IL ‐21 for Ig production. Overall, results from this study suggest that Th17 cells from glaucoma patients present elevated capacity to stimulate Ig production.
机译：发明内容升高的自身抗体表达是青光眼免疫失调的标志，可能导致视网膜神经节细胞凋亡和免疫介导的神经损伤，从而有助于盲目的发展。自身抗体上调的原因仍然尚不清楚。显示Th17细胞促进自身免疫和IG生产。在这里，我们证明白细胞介素（IL）-17A和IL -21的血清水平与青光眼患者和非青光眼对照之间的相当。然而，Th17促进细胞因子的水平，例如肿瘤坏死因子（TNF）IL -6，葡萄糖患者患者高于对照组。随后，我们证明青光眼患者呈现出静脉体内静态的静态的上调水平。有趣的是，与来自非青光眼受试者的Th17细胞相比，来自青光眼患者的Th17细胞具有类似的IL -17A生产能力，但显着提高IL -21生产能力。鉴于IL -21也被描述为滤泡辅助T细胞的特异性细胞因子，研究了与循环Th17细胞共孵育后的B细胞的IG产生。来自青光眼患者的Th17细胞显着增强了促进IG产生的潜力而不是来自对照的Th17细胞。青光眼患者Th17细胞和对照Th17细胞都需要IL -17A和IL -21进行IG生产。总体而言，本研究结果表明，来自青光眼患者的Th17细胞刺激IG生产的升高能力。

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  • 作者

    Ren Yongbo; Qi Yanxiu; Su Xingjie;

  • 作者单位

    Department of OphthalmologyThe First Affiliated Hospital of Jiamusi UniversityJiamusi Heilongjiang;

    Department of OphthalmologyThe First Affiliated Hospital of Jiamusi UniversityJiamusi Heilongjiang;

    Department of OphthalmologyThe First Affiliated Hospital of Jiamusi UniversityJiamusi Heilongjiang;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    glaucoma; Tfh; Th17;

    机译：青光眼;TFH;TH17;

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