...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage
【24h】

Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage

机译：在鼠蛛网膜瘤出血后急性脑缺氧和机车缺血性延迟延迟恢复

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Tooth loss and related changes in the functionality may lead to worse outcome of stroke patients, but the effect on hemorrhagic stroke remains unclear. This study aimed to determine the impact of impaired masticatory function on acute cerebral oxygenation and locomotor activity after experimental subarachnoid haemorrhage ( SAH ). Twenty C57 BL /6 mice with (MC‐treated group) or without (control group) prior treatment of cutting off the upper molars were subjected to SAH by endovascular perforation. Grading of SAH and acute cerebral infarction were assessed by MR images. Brain tissue oxygen saturation (SbtO 2 ) by photoacoustic imaging and parameters related to locomotor activity by open‐field test were analyzed serially after SAH . In all mice, global SbtO2 depression was notable immediately after SAH induction ( P ?.001), which recovered close to the baseline levels until day 3. However, MC‐treated mice demonstrated a prolonged relative cerebral hypoxia (40% of the baseline SbtO2) as compared to the control (3?±?1 vs 1?±?1?days; P? .05). The average distance travelled on day 7 and the ratio of central‐area distance/total travelled distance by open‐field test between days 7 and 14 were significantly lower in MC‐treated mice than in the control mice ( P ?.05), although the occurrences of new infarction were not statistically different ( P ?.05). These data suggest a possible link between preceding masticatory impairment and early brain injury to deteriorate neurobehavioural function in patients after SAH .
机译：总结牙齿损失和相关变化的功能可能导致中风患者的较差，但对出血性卒中的影响仍然不清楚。本研究旨在确定咀嚼咀嚼作用对实验性蛛网膜下腔（SAH）后急性脑氧合和运动活性的影响。用（MC-处理组）或不含（对照组）的二十C57Bl / 6只小鼠通过血管外穿孔进行切断上部磨牙的预先处理。通过MR图像评估SAH和急性脑梗塞的评分。通过光声成像（SBTO 2）通过光声成像（SBTO 2）通过开放场测试进行光声成像和与运动活性相关的参数进行分析。在所有小鼠中，全局SbTo2凹陷在SAH诱导（p≤00）后立即显着，该抑制在第3天之前恢复到基线水平靠近3.然而，MC处理的小鼠展示了延长的相对脑缺氧（＆ 40％）基线SBTO2）与对照相比（3？±1 Vs 1？±1？天; p？＆ 05）。在第7天行驶的平均距离和中央区域距离/总行驶距离在MC处理小鼠中明显低于对照小鼠的显着低（P？≤05）虽然新梗死的发生并没有统计学不同（p？＆ .05）。这些数据表明，在SAH后患者患者中，咀嚼损伤和早期脑损伤之间的可能链接。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号