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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats
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Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats

机译：Spexin和孕酮对卵巢切除大鼠疼痛敏感性衰减的协同作用

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Summary Spexin is a central modulator of nociception. The aim of the present study was to investigate the effect of intra‐hippocampal CA 3 ( IHCA 3) injection of spexin and spexin‐progesterone co‐administration on pain sensitivity in ovariectomized rat. Thirty‐five adult female rats were divided into five groups. Sham: the animals received injection of 0.5?μL ACSF by IHCA 3. Experiments 1 and 2: the animals received injection of 0.5?μL of spexin bilaterally (10 and 30?nmol/rat respectively). Experiments 3 and 4: the animals received injection of 0.5?μL of spexin bilaterally (10 and 30?nmol/rat respectively)?+?subcutaneous (s.c.) injection of progesterone (5?mg/kg). Ovariectomy was performed in all groups to eliminate the effects of cyclic changes in the female rats. The formalin test (formalin 2.5%) was performed following the administration of spexin and progesterone. Results showed that bilateral injection of spexin in IHCA 3 at both concentrations a significant ( P ??.05) decrease in the pain sensitivity in the two phases of formalin test. Similarly, the bilateral injection of spexin in IHCA 3 at both concentrations following the s.c. injection of progesterone significantly ( P ??.05) decreases pain sensitivity in two phases of the formalin test. This pain attenuation due to the co‐administration of spexin and progesterone was more potent than spexin‐induced analgesia. According to the present results, spexin has a modulatory effect on pain sensitivity, which becomes more pronounced by progesterone administration.
机译：发明内容斑蛋白是伤害伤害的中央调制器。本研究的目的是探讨卵巢内瘤和斑蛋白 - 孕酮共注入卵菜和斑蛋白 - 孕酮共注入卵巢切除大鼠疼痛敏感性的影响。三十五名成年女性大鼠分为五组。假说明的动物通过IHCA 3.实验1和2所接受0.5·μlACSF的注射：动物分别接受0.5×μl的双侧（分别为10和30 = Nmol /大鼠的动物。实验3和4：将动物分别接受0.5〜μl的双侧（分别为10和30 = Nmol / R大鼠的斑点（10-30℃）α+？皮下（S.C.）注射孕酮（5？Mg / kg）。在所有基团中进行卵巢切除术，以消除雌性大鼠循环变化的影响。在给药后嗅觉和孕酮进行福尔马林试验（福尔马林2.5％）。结果表明，两种浓度在福尔马林试验中两相的疼痛敏感性下降（p≤1，05），两侧在两种浓度下降的斑蛋白。类似地，在S.C的两种浓度下，IHCA 3中的双侧注射斑蛋白。显着注射孕酮（p？＆ 05）降低福尔马林试验的两阶段的疼痛敏感性。由于斑蛋白和孕酮的共同施用而导致的这种疼痛衰减比斑蛋白诱导的镇痛更有效。根据目前的结果，Spexin对疼痛敏感性具有调节作用，这对黄体酮给药变得更加明显。

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