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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Drug‐resistant epilepsy and topiramate: Plasma concentration and frequency of epileptic seizures
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Drug‐resistant epilepsy and topiramate: Plasma concentration and frequency of epileptic seizures

机译：耐药性癫痫和托吡酯：血浆浓度和癫痫发作的频率

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Summary Topiramate ( TPM ) is a second‐generation antiepileptic drug ( AED ), acting on drug‐resistant epilepsy. The aim of the study was to evaluate the influence of the dose, use of other AED s on TPM plasma concentration ( C p ), and frequency of epileptic seizures. A cross‐sectional analytical study was developed with patients aged 18‐60?years, for diagnosis of drug‐resistant epilepsy, using TPM in monotherapy or associated with other AED s. The following variables were analyzed: age, frequency of epileptic seizures, pharmacotherapeutic regimen with its respective doses, adherence to medication treatment, and adverse events score. Thirty‐seven patients were included, 83.8% of the patients presented C p below the therapeutic range. Multiple linear regression estimated that the increase of 1.0?mg/kg/d promoted an increase of 0.68?μg/ mL in TPM C p , while the use of inducers predicted a reduction of 2.97?μg/ mL ( P ??.001). Multiple Poisson regression predicts that an increase of 1.0?μg/ mL in TPM C p decreased the patient's chance of presenting seizures, and patients using AED inducers were about ten times more likely to present seizures than those who do not use ( P ??.001). In addition, for patients using AED inducers with C p below the therapeutic range, the mean number of seizures per month was greater than those with C p within the therapeutic range. The prescribed dose and the use of AED inducers influence C p of TPM , likewise the low C p of first‐line AED s and of the adjuvant in the treatment, TPM , as well as low TPM dose seem to affect the control of epileptic seizures.
机译：发明内容Topiramate（TPM）是第二代抗癫痫药物（AED），作用于耐药性癫痫。该研究的目的是评估剂量的影响，其他AED S对TPM血浆浓度（C P）的影响，以及癫痫发作的频率。横截面分析研究是用18-60岁的患者开发的，用于诊断耐药性癫痫，使用TPM在单疗法中或与其他AED相关联。分析以下变量：年龄，癫痫发作的频率，药物治疗方案及其各自剂量，依从药物治疗，以及不良事件得分。包括三十七名患者，83.8％的患者呈现在治疗范围以下C p。多元线性回归估计在TPM C P中增加1.0毫克/ kg / d促进升高0.68Ωμg/ ml，而诱导剂的使用预测为2.97ΩΩ×ml（p≤≤1。 001）。多元泊松回归预测TPM C P中的1.0μg/ ml的增加降低了患者患者的癫痫发作的可能性，并且使用AED诱导剂的患者呈现出癫痫发作的可能性比不使用的患者（p？＆ ？.001）。此外，对于使用治疗范围低于C p的诱导剂的患者，每月癫痫发作的平均数量大于治疗范围内的C p。规定的剂量和使用AED诱导剂的使用影响TPM的C p，同样地是在治疗中的第一线AED S和佐剂的低C p，TPM以及低TPM剂量似乎影响癫痫发作的控制。

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