...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Patient characteristics associated with peglyated interferon alfa‐2a induced neutropenia in chronic hepatitis C patients
【24h】

Patient characteristics associated with peglyated interferon alfa‐2a induced neutropenia in chronic hepatitis C patients

机译：患有肺型干扰素ALFA-2A诱导的慢性丙型肝炎患者的患者特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Neutropenia is a haematologic disorder commonly reported in patients with chronic hepatitis C virus ( HCV ) infection treated with pegylated interferon alfa‐2a ( PEG ‐ IFN α‐2a). The objective of the present project is to identify patient characteristics associated with neutropenia in hepatitis C patients. Demographic, clinical, and genetic data from 715 patients with chronic HCV infection treated with PEG ‐ IFN α‐2a and ribavirin. The outcome variable was the development of grade 3 or 4 neutropenia, defined as the decrease in neutrophil counts below 1?10 9 /L anytime during study. Predictors of neutropenia were identified using a 2‐stage approach. First, univariate analysis was performed to identify possible predictors of neutropenia. T test was used for continuous variables and Fisher's exact test was used for categorical variables. Second, multiple logistic regression with stepwise addition was then performed using predictors identified in the univariate analysis step to produce final model containing independent predictors at P ??.05. Logistic regression identified female gender, absolute neutrophils counts, and cholesterol level as the main predictors of neutropenia. Female gender increases the odds of experiencing neutropenia by 86% compared to male gender. A 1 unit (mmol/L) increase in cholesterol level decreases the odds of developing neutropenia by 13%. A 55% reduction in the likelihood of developing neutropenia for a 1 unit (10 9 /L) increase in the absolute neutrophils counts. Patients with high risk of developing neutropenia can be identified. Identification of this cohort allows early intervention to prevent neutropenia. Possible intervention is to administer drugs that raise neutrophil count such as filgrastim before neutropenia occurs.
机译：概述中性粒细胞病毒是一种常常报道的患有聚乙二醇干扰素ALFA-2a（PEG - IFNα-2a）处理的慢性丙型肝炎病毒（HCV）感染患者的血液学疾病。本项目的目的是鉴定与丙型肝炎患者中型细胞减少症相关的患者特征。 715例用PEG - IFNα-2A和利巴韦林治疗715例慢性HCV感染患者的人口统计学，临床和遗传数据。结果变量是3级或4级中性粒细胞凋亡的发展，定义为在研究​​期间随时下降到1？10 9 / L的下降次数。使用2阶段方法鉴定中性细胞病的预测因素。首先，进行单变量分析以识别中性粒细胞减少症的可能预测因子。 T测试用于连续变量，使用Fisher的确切测试用于分类变量。其次，然后使用单变量分析步骤中识别的预测器来进行逐步添加的多重逻辑回归，以在p =α中产生含有独立预测器的最终模型。05。逻辑回归鉴定了女性性别，绝对中性粒细胞计数和胆固醇水平作为中性粒细胞凋亡的主要预测因子。与男性性别相比，女性性别增加了86％的体育中心病的几率。胆固醇水平的1个单元（MMOL / L）增加降低了发育中性粒细胞减少的几率13％。在绝对中性粒细胞计数的1单位（10 9 / L）增加的中性粒细胞减少的可能性下降55％。可以鉴定发育中性粒细胞率高风险的患者。鉴定该队列允许早期干预以防止中性粒细胞减少症。可能的干预是施用药物，使中性粒细胞计数如菲格拉斯氏植物在中性粒细胞减少之前进行。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号