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Exploring the Abnormal Brain Regions and Abnormal Functional Connections in SZ by Multiple Hypothesis Testing Techniques

机译：多个假设检测技术探索SZ异常脑区和异常功能连接

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摘要

Schizophrenia (SZ) is one of the most common mental diseases. Its main characteristics are abnormal social behavior and inability to correctly understand real things. In recent years, the magnetic resonance imaging (MRI) technique has been popularly utilized to study SZ. However, it is still a great challenge to reveal the essential information contained in the MRI data. In this paper, we proposed a biomarker selection approach based on the multiple hypothesis testing techniques to explore the difference between SZ and healthy controls by using both functional and structural MRI data, in which biomarkers represent both abnormal brain functional connectivity and abnormal brain regions. By implementing the biomarker selection approach, six abnormal brain regions and twenty-three abnormal functional connectivity in the brains of SZ are explored. It is discovered that compared with healthy controls, the significantly reduced gray matter volumes are mainly distributed in the limbic lobe and the basal ganglia, and the significantly increased gray matter volumes are distributed in the frontal gyms. Meanwhile, it is revealed that the significantly strengthened connections are those between the middle frontal gyms and the superior occipital gyms, the superior occipital gyms and the middle occipital gyms as well as the middle occipital gyms and the fusiform gyms, and the rest connections are significantly weakened.
机译：精神分裂症（SZ）是最常见的精神疾病之一。其主要特征是异常的社会行为，无法正确地了解真实的东西。近年来，磁共振成像（MRI）技术普遍地利用来研究SZ。但是，揭示MRI数据中包含的基本信息仍然是一个巨大的挑战。在本文中，我们提出了一种基于多假设检测技术的生物标志物选择方法，通过使用功能和结构MRI数据来探讨Sz和健康对照的差异，其中生物标志物代表异常脑功能连接和异常脑区域。通过实施生物标志物选择方法，探讨了六个异常的脑区和SZ大脑中的23个异常功能连通性。发现与健康对照相比，显着减少的灰质体积主要分布在肢叶和基底神经节中，并且显着增加的灰质体积分布在正面健身房。同时，据透露，显着加强的联系是中正面健身房和高级枕部健身房，高级枕骨健身房和中部枕垫体系以及中间枕垫和梭形健身房的联系，以及其余的连接都很明显削弱了。

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