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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Effect of fractal-shaped outer boundary of glioblastoma multiforme on drug delivery
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Effect of fractal-shaped outer boundary of glioblastoma multiforme on drug delivery

机译：胶质母细胞瘤多形外边界对药物递送的影响

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摘要

Background and objective: The present study investigates the transport of drugs in the proximity of the glioblastoma multiforme, a brain neoplasm which is regarded to be the most aggressive type of cancer. In such a small distance from the tumor, diffusion dominates and is driven by the concentration gradient of drug that acquires its maximum at regions where the drugs are released and its minimum at the cancer cell boundary. Undoubtedly, the morphology of the aforementioned boundary is going to play a crucial role in the drug delivery and should be taken into account for the optimal design of the treatment. As first step in order to simulate the topography of glioblastoma multiforme, a fractal boundary is examined which mimics an acceptable model-problem for prognosis and diagnosis of a number of cancer tumors in breast, lungs and brain.
机译：背景和目的：本研究调查了胶质母细胞瘤多形态瘤的脑肿瘤，脑肿瘤的邻近的运输是最具侵略性的癌症。 在距肿瘤的这种小距离中，扩散主导并由药物的浓度梯度驱动，该药物在释放药物的地区的最大值及其在癌细胞边界处的最小值。 毫无疑问，上述边界的形态将在药物递送中发挥至关重要的作用，应考虑到治疗的最佳设计。 作为模拟胶质母细胞瘤的地形多形状的第一步，检查了分形边界，其模仿可接受的模型问题以进行乳腺癌，肺癌和脑中许多癌症肿瘤的预后和诊断。

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