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首页> 外文期刊>Computers in Biology and Medicine >Permeability and fluid flow-induced wall shear stress of bone tissue scaffolds: Computational fluid dynamic analysis using Newtonian and non-Newtonian blood flow models
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Permeability and fluid flow-induced wall shear stress of bone tissue scaffolds: Computational fluid dynamic analysis using Newtonian and non-Newtonian blood flow models

机译：骨组织支架的渗透性和流体流动诱导的壁剪应力：使用牛顿和非牛顿血流模型的计算流体动力学分析

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摘要

Among the factors that are important in successful bone tissue regeneration through scaffolds are permeability and fluid flow-induced wall shear stress (WSS) because of the direct contribution of these factors to cell bioactivities. The permeability of scaffolds is usually measured using fluids such as water, which are characterized as Newtonian materials with constant viscosity. However, using the fluid properties of blood as bases in measuring permeability can lead to more realistic results given that scaffolds are implanted in the body, where the only flowing fluid (i.e., blood) is a non-Newtonian fluid. Moreover, the linear relationship of WSS with fluid viscosity challenges the use of Newtonian fluids in determining WSS magnitude. With consideration for these issues, we investigated permeability and WSS through computational fluid dynamics (CFD) analyses of lattice-based and gyroid scaffold architectures with Newtonian and non-Newtonian blood flow properties. With reference to geometrical parameters and the pressure drops derived from the CFD analyses, the permeability levels of the Newtonian and non-Newtonian models were calculated by exploiting the classic and modified Darcy's equations, respectively. Results showed that both scaffold architectures were several times more permeable in the Newtonian blood flow models than in their non-Newtonian counterparts. Within the scaffolds, the non-Newtonian flow of blood caused almost twice the magnitude of WSS originating from Newtonian blood flow. These striking discrepancies in permeability and WSS between the two blood models were due to differences in their viscosity behaviors.
机译：在通过支架上成功的骨组织再生是重要的因素中，由于这些因素对细胞生物活性的直接贡献，渗透性和流体流动诱导的壁剪切应力（WSS）。支架的渗透性通常使用诸如水的流体测量，其特征在于具有恒定粘度的牛顿材料。然而，使用血液的流体性质作为测量渗透性的碱可以导致更现实的结果，因为支架植入体内，其中唯一流动的流体（即血液）是非牛顿液。此外，WSS具有流体粘度的线性关系挑战使用牛顿流体在确定WSS幅度时的使用。考虑到这些问题，我们通过使用牛特和非牛顿血流特性的晶格基和陀螺脚手架架构的计算流体动力学（CFD）分析来调查渗透率和WSS。参考几何参数和源自CFD分析的压降，通过分别利用经典和修改的达西公式来计算牛顿和非牛顿模型的渗透率水平。结果表明，两辆脚手架架构在牛顿血流模型中渗透多次，而不是在非牛顿对应上。在脚手架内，非牛顿的血液流量几乎是源自牛顿血流的效率的两倍。这些渗透率和两种血液模型之间的围绕差异差异是由于它们的粘度行为的差异。

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