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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >Anti-Müllerian hormone levels in salpingectomized compared with nonsalpingectomized women with tubal factor infertility and women with unexplained infertility
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Anti-Müllerian hormone levels in salpingectomized compared with nonsalpingectomized women with tubal factor infertility and women with unexplained infertility

机译：与输卵管因素不育和不明原因不孕妇女相比，输卵管切除术和非输卵管切除术妇女的抗苗勒管激素水平

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Objective To investigate the consequence of salpingectomy on ovarian reserve by measuring anti-Müllerian hormone (AMH) levels before in vitro fertilization (IVF) treatment in salpingectomized women compared with nonsalpingectomized women with tubal factor infertility, women with unexplained infertility and fertile control women, and to evaluate whether AMH levels could predict IVF outcome. Design Cross-sectional study extended from a previous prospective study. Setting Four university fertility clinics. Patients Seventy-one women with infertility and 21 fertile controls. Interventions Blood sampling and IVF and embryo transfer in the following cycle. Main outcome measure Serum AMH levels and oocytes retrieved. Results Anti-Müllerian hormone levels were significantly lower in the salpingectomy infertility group (median 16.1, range 5.2-54 pmol/L) compared with the nonsalpingectomy tubal factor infertility group (median 23.4, range 3.5-50 pmol/L; p = 0.04). In all groups, AMH levels correlated positively with the number of oocytes retrieved. AMH predicted poor response (five or fewer oocytes) with a sensitivity and specificity of 90% and 70%, at a 19 pmol/L cut-off value. Conclusion Serum AMH levels were lower in salpingectomized women compared with women with tubal factor infertility and preserved Fallopian tubes, indicating that ovarian reserve might be affected by tubal surgery. Furthermore, serum AMH levels could predict a poor oocyte response (five or fewer oocytes) in the study group of infertile women.
机译：目的通过测量经输卵管切除的女性与未输卵管切除不育的输卵管因素不育女性，不明原因的不育女性和受精控制女性相比，经输卵管切除的女性进行体外受精（IVF）治疗前的抗苗勒管激素（AMH）水平，以探讨输卵管切除术对卵巢储备的影响。评估AMH水平是否可以预测IVF结果。设计横断面研究是从先前的前瞻性研究扩展而来的。设置四所大学生育诊所。患者71名不育妇女和21名受精对照妇女。干预措施在下一个周期中进行血液采样，IVF和胚胎移植。主要结局指标血清AMH水平和回收的卵母细胞。结果输卵管切除术不育组的抗苗勒管激素水平显着降低（中位数16.1，范围5.2-54 pmol / L），而非输卵管切除术输卵管因素不育组（中位数23.4，范围3.5-50 pmol / L; p = 0.04） 。在所有组中，AMH水平与回收的卵母细胞数量呈正相关。 AMH以19 pmol / L的临界值预测了较差的反应（卵母细胞数为5个或更少），灵敏度和特异性分别为90％和70％。结论与输卵管不育和保留输卵管的妇女相比，输卵管切除术的妇女血清AMH水平较低，这表明输卵管手术可能会影响卵巢储备。此外，在不育妇女研究组中，血清AMH水平可以预测较差的卵母细胞反应（5个或更少的卵母细胞）。

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