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首页> 外文期刊>Clinical and experimental allergy : >The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality?
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The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality?

机译：早期生命接触抗生素和哮喘，湿疹和特性的关联，在出生时队列：混淆或因果关系？

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BACKGROUND: In general, studies reporting positive associations between antibiotic exposure and respiratory and allergic disease have been unable to determine the nature of this association. OBJECTIVE: To examine the association between antibiotic exposure in infancy and the development of asthma, eczema and atopy in early childhood. METHODS: In a birth cohort study, we collected reported antibiotic exposure before 3 months and before 15 months along with outcomes (wheeze, asthma, eczema, rash, inhaler use) at 15 months (n=1011) and 4 years (n=986). Atopy was measured using skin prick tests at 15 months. RESULTS: We found significant univariate associations of antibiotic exposure before 3 months with asthma developing between birth and 15 months [OR 2.32 (95% CI 1.45-3.69)]. After adjustment for chest infections, this association reduced (OR=1.58, 95% CI 0.96-2.60) becoming marginally significant (P=0.07). A marginally significant association of antibiotics with atopy (OR=1.44, 95% CI 0.96-2.14) in the univariate analysis also reduced after adjustment for chest infections (OR=1.36, 95% CI 0.91-2.05). There was no effect of antibiotic exposure before 15 months on asthma developing after 15 months and present between 3 and 4 years (OR=1.35 95% CI 0.85-2.14). Antibiotic exposure before 3 months was not associated with eczema and rash developing between birth and 15 months but exposure before 15 months was related to eczema [OR 1.83 (95% CI 1.10-3.05)] and rash [OR 1.61 (95% CI 1.02-2.53)] developing after 15 months and remaining present at 4 years. These effects reduced in the multivariate analysis. CONCLUSIONS: Our findings suggest that the effect of antibiotics on respiratory disease may be due to confounding by chest infections at an early age when asthma may be indistinguishable from infection.
机译：背景：一般来说，报告抗生素暴露和呼吸道和过敏性疾病之间的阳性关联的研究无法确定本协会的性质。目的：审查婴儿期抗生素暴露与哮喘，湿疹和幼稚患者的开发之间的关联。方法：在出生队列研究中，我们在3个月和15个月之前收集了抗生素暴露，以及15个月（n = 1011）和4年（n = 986）的结果（喘息，哮喘，湿疹，皮疹，吸入器使用）（n = 986） ）。在15个月使用皮肤刺试验测量Atopate。结果：我们发现在3个月之前发现了抗生素暴露的重要协会，哮喘在出生之间和15个月之间发展[或2.32（95％CI 1.45-3.69）]。调整胸部感染后，该关联降低（或= 1.58,95％CI 0.96-2.60）略微显着（P = 0.07）。在胸部感染的调节后，单变量分析中的特性分析（或= 1.44,95％CI 0.96-2.14）的抗生素略微显着，在胸部感染（或= 1.36,95％CI 0.91-2.05）调节后也减少了单变量分析。在15个月后15个月之前，在15个月后，在3至4岁以下（或= 1.35 95％CI 0.85-2.14）之间没有抗生素暴露于15个月之前的影响。 3个月之前的抗生素暴露与湿疹和出生之间的皮疹发育不相关，但在15个月之前发生暴露于15个月之前与湿疹有关[或1.83（95％CI 1.10-3.05）]和皮疹[或1.61（95％CI 1.02- 2.53）] 15个月后发展，4年的剩余活动。这些效果减少了多变量分析。结论：我们的研究结果表明，抗生素对呼吸系统疾病的影响可能是由于哮喘患者在感染中无法区分时胸部感染的混淆。

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