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Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

机译：暴露于宠物和潮湿或模具时序对哮喘和青春期致敏的作用

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Abstract Background Pet and dampness or mould exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence. Objective We investigated the role of timing of pet and dampness or mould exposure in asthma and sensitization in adolescence. Understanding this role is essential to build targeted prevention strategies. Methods We used data from 1871 participants of the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. Residential exposure to pets, dampness or mould was assessed by repeated parental questionnaires. We used asthma data from the 17‐year questionnaire and sensitization data from the 16‐year medical examination. We characterized timing using longitudinal exposure patterns from pregnancy till age 17 using longitudinal latent class growth modelling. We used logistic regression models to analyse associations of exposure patterns with asthma at age 17 and sensitization at age 16. Results For none of the time windows, exposure to pets and dampness or mould was associated with asthma at age 17, but a lower sensitization risk at age 16 was suggested, for example the odds ratio (95% confidence interval) for sensitization was 0.63 (0.35‐1.11) and 0.69 (0.44‐1.08) for early life and persistently high pet exposure, respectively, compared with very low exposure. An inverse association was also suggested for sensitization and moderate early childhood dampness or mould exposure (0.71 [0.42‐1.19]). Conclusion and clinical relevance Different timing of pet and dampness or mould exposure was not associated with asthma, but lower risk of sensitization in adolescence was suggested, which could be partly attributable to reversed causation. Current findings are not sufficient to recommend pet avoidance to prevent allergic disease. More prospective studies are needed to obtain insights that can be used in clinical practice.
机译：摘要背景宠物和潮湿或液体暴露被认为是哮喘和敏化的风险因素。目前尚不清楚暴露于这些因素的时间是否与哮喘风险和青春期的敏化差异。目的我们调查了宠物和潮湿或模具暴露在哮喘和青春期敏化中的作用。了解此角色对于建立有针对性的预防策略至关重要。方法采用来自1871年的荷兰和螨虫过敏（PiAma）队列的1871年参与者的数据。通过重复的父母问卷评估宠物，湿度或模具的住宅暴露。我们从16年体检中使用了来自17年的问卷调查问卷和敏感数据的哮喘数据。我们使用纵向潜入阶级增长模拟使用纵向曝光模式的纵向暴露模式来表征时间。我们使用Logistic回归模型来分析17岁以上哮喘的暴露模式与哮喘的关联，并且在16岁时致敏。没有时间窗口，接触宠物和潮湿或模具的结果与17岁的哮喘有关，但致敏风险较低在16岁时建议，例如，对于早期寿命和持续高宠物暴露，致敏的致敏比（95％置信区间）为0.63（0.35-1.11）和0.69（0.44-1.08）。还提出了逆关节，用于致敏和中等儿童潮湿或霉菌暴露（0.71 [0.42-1.9]）。结论及临床相关性不同于宠物和潮湿或模具暴露的时间与哮喘无关，但提出了较低的青春期敏化风险，这可能是逆转因果关系的部分归因于逆转因果关系。目前的调查结果不足以推荐宠物避免以防止过敏性疾病。需要更多的前瞻性研究来获得可用于临床实践的见解。

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