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首页> 外文期刊>Allergy >Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative.
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Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative.

机译：欧洲八个出生队列对哮喘和过敏的霉菌和潮湿暴露的荟萃分析：ENRIECO计划。

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BACKGROUND: Several cross-sectional studies during the past 10 years have observed an increased risk of allergic outcomes for children living in damp or mouldy environments. OBJECTIVE: The objective of this study was to investigate whether reported mould or dampness exposure in early life is associated with the development of allergic disorders in children from eight European birth cohorts. METHODS: We analysed data from 31 742 children from eight ongoing European birth cohorts. Exposure to mould and allergic health outcomes were assessed by parental questionnaires at different time points. Meta-analyses with fixed- and random-effect models were applied. The number of the studies included in each analysis varied based on the outcome data available for each cohort. RESULTS: Exposure to visible mould and/or dampness during first 2 years of life was associated with an increased risk of developing asthma: there was a significant association with early asthma symptoms in meta-analyses of four cohorts [0-2 years: adjusted odds ratios (aOR), 1.39 (95% CI, 1.05-1.84)] and with asthma later in childhood in six cohorts [6-8 years: aOR, 1.09 (95% CI, 0.90-1.32) and 3-10 years: aOR, 1.10 (95% CI, 0.90-1.34)]. A statistically significant association was observed in six cohorts with symptoms of allergic rhinitis at school age [6-8 years: aOR, 1.12 (1.02-1.23)] and at any time point between 3 and 10 years [aOR, 1.18 (1.09-1.28)]. CONCLUSION: These findings suggest that a mouldy home environment in early life is associated with an increased risk of asthma particularly in young children and allergic rhinitis symptoms in school-age children.
机译：背景：在过去的十年中，一些横断面研究已经观察到生活在潮湿或发霉环境中的儿童变态反应结果的风险增加。目的：本研究的目的是调查来自欧洲8个出生队列的儿童早期报告的霉菌或潮湿暴露是否与过敏性疾病的发展有关。方法：我们分析了来自八个正在进行的欧洲出生队列的31 742名儿童的数据。通过父母问卷在不同时间点评估霉菌暴露和过敏性健康结局。应用具有固定和随机效应模型的荟萃分析。每个分析中包含的研究数量根据每个队列的可用结果数据而有所不同。结果：在生命的最初2年中暴露于可见的霉菌和/或潮湿与患哮喘的风险增加相关：在4个队列的荟萃分析中，与早期哮喘症状显着相关[0-2岁：校正后的机率比率（aOR）为1.39（95％CI，1.05-1.84）]，并在六个队列中[6-8岁：aOR，1.09（95％CI，0.90-1.32）和3-10岁：aOR]在儿童期晚期出现哮喘，1.10（95％CI，0.90-1.34）]。在学龄期[6-8岁：aOR，1.12（1.02-1.23）]以及3至10岁之间的任何时间点[aOR，1.18（1.09-1.28），在六个有变应性鼻炎症状的队列中，观察到统计学上显着的关联。 ）]。结论：这些发现表明，早期的发霉家庭环境与哮喘风险增加有关，尤其是在幼儿和学龄儿童的过敏性鼻炎症状方面。

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