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首页> 外文期刊>Comparative clinical pathology >Gallic acid reduces inflammatory cytokines and markers of oxidative damage in a rat model of estradiol-induced polycystic ovary
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Gallic acid reduces inflammatory cytokines and markers of oxidative damage in a rat model of estradiol-induced polycystic ovary

机译：Gallic acid减少了雌二醇诱导的多囊卵巢大鼠模型中的炎症细胞因子和氧化损伤标记

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Hormonal disorders, oxidative stress, and inflammation in ovarian tissue cause ovulation failure in women with polycystic ovary syndrome. Considering the antioxidant properties of gallic acid (GA), the aim of this study was to investigate the effect of GA on pro-inflammatory cytokines, antioxidant enzyme activity, and DNA oxidative damage of ovarian tissue in a rat model of estradiol-induced polycystic ovary (PCO). In this experimental study, 32 female Wistar rats were divided into four groups. These included control (saline solution, orally), PCO+saline (estradiol valerate + saline solution, orally), PCO+GA50, and PCO+GA100 (estradiol valerate +50 and 100 mg/kg gallic acid, orally), respectively. The PCO model was induced by a single intramuscular injection of estradiol valerate (EV, 4 mg/kg). Twenty-four days after PCO modeling, tissue concentration of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) and also the activity level of superoxide dismut-ase (SOD), catalase (CAT), glutathione peroxidase (GPX), malondialdehyde (MDA), and 8-oxo-2'-deoxyguanosine (8-OHdG) in ovarian tissue were measured through ELISA technique. Compared with the PCO+saline, in the GA-treated group, the concentration of TNF-α, IL-1β, and IL-6 in a dose-dependent manner significantly decreased (p > 0.05). In addition, the activity level of SOD, CAT, and GPX enzymes significantly increased (p < 0.05), while the amount of MDA and 8-OHdG significantly decreased (p > 0.05) in a dose-dependent manner. GA is an anti-inflammatory and an antioxidant polyphenol which reduces the concentration of inflammatory cytokines, oxidative stress, lipid peroxidation, and DNA oxidative damage of ovarian tissue in a rat's model of PCO.
机译：卵巢组织中的激素紊乱，氧化应激和炎症导致患有多囊卵巢综合征的妇女排卵失败。考虑到GALIC酸（GA）的抗氧化性质，本研究的目的是研究GA对雌激素诱导的多囊卵巢大鼠模型中卵巢组织对促炎细胞因子，抗氧化酶活性和DNA氧化损伤的影响（PCO）。在该实验研究中，将32只雌性Wistar大鼠分为四组。这些包括对照（盐水溶液，口服），PCO +盐水（雌二醇戊酸盐+盐水溶液，口服），PCO + GA50和PCO + GA100（雌二醇戊酸+ 50和100mg / kg Gallic酸，口服）。通过单一肌肉注射雌二醇（EV，4mg / kg）诱导PCO模型。 PCO建模后二十四天，肿瘤坏死因子α（TNF-α），白细胞介素-1β（IL-1β），和白细胞介素-6（IL-6）以及超氧化物令人沮丧 - ASE的活性水平（通过ELISA技术测量SOD），过氧化氢酶（猫），谷胱甘肽过氧化物酶（GPX），丙二醛（MDA）和8-氧代-2'-脱氧核苷酸（8-OHDG）。与PCO +盐水相比，在GA处理基团中，以剂量依赖性方式浓度为TNF-α，IL-1β和IL-6的浓度显着降低（P> 0.05）。此外，SOD，猫和GPX酶的活性水平显着增加（P <0.05），而MDA和8-OHDG的量以剂量依赖性方式显着降低（P> 0.05）。 Ga是一种抗炎和抗氧化多酚，可降低炎症细胞因子，氧化应激，脂质过氧化的浓度，卵巢组织的PCO模型中的卵巢组织的浓度。

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