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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >Age-related distributions of anti-Müllerian hormone level and anti-Müllerian hormone models
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Age-related distributions of anti-Müllerian hormone level and anti-Müllerian hormone models

机译：抗苗勒管激素水平和抗苗勒管激素模型的年龄相关分布

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Objective. To determine age-specific reference values for anti-Müllerian hormone (AMH) and to set up an optimal model for AMH changes by age for infertility investigations. Design. Prospective study. Setting. Several infertility clinics and two university hospitals. Sample. A total of 21 226 AMH samples were obtained. Methods. Data on patients' age, race/ethnicity, and AMH levels were available from the laboratory center data registry between November 2008 and January 2011. Main outcome measures. The distribution of AMH levels by age. From 16 972 women aged between 25 and 45 years, we established and validated five AMH-age regression models. Results. The overall mean AMH level was 4.09 ± 3.71 ng/mL (median: 3.13 ng/mL). There was an inverse relation between AMH level and age. Among multiple regression models, the quadratic model was most appropriate to describe AMH-age relation (log AMH = 0.205 × age - 0.005 × age 2- 0.047). Conclusions. AMH levels show a progressive decline with increasing age. Age-specific AMH values may provide more specific information useful for patients and clinicians. AMH-age models could play a role as a basic step to approach more accurate ovarian reserve estimation.
机译：目的。为了确定抗苗勒氏管激素（AMH）的特定年龄参考值，并为不育调查建立按年龄划分的AMH变化的最佳模型。设计。前瞻性研究。设置。几个不孕诊所和两家大学医院。样品。总共获得21 226个AMH样品。方法。在2008年11月至2011年1月之间，可从实验室中心数据注册处获得有关患者年龄，种族/民族和AMH水平的数据。主要结局指标。 AMH水平按年龄的分布。我们从16 972名年龄在25至45岁之间的女性中，建立并验证了五个AMH年龄回归模型。结果。总体平均AMH水平为4.09±3.71 ng / mL（中位数：3.13 ng / mL）。 AMH水平与年龄之间呈反比关系。在多元回归模型中，二次模型最适合描述AMH与年龄的关系（log AMH = 0.205×年龄-0.005×年龄2-0.047）。结论随着年龄的增长，AMH水平显示逐渐下降。特定年龄的AMH值可能会提供对患者和临床医生有用的更具体的信息。 AMH年龄模型可以作为更准确地评估卵巢储备量的基本步骤。

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