目的:探讨生育期女性血清抗苗勒管激素(AMH)水平与年龄及血清性激素水平的关系.方法:回顾性收集本院就诊的生育期女性719例的血清AMH和血清促卵泡生成激素(FSH)、黄体生成素(LH)、睾酮(T)、雌二醇(E2)、孕酮(P)检测记录,分为高龄组(38～45岁)及对照组(23～37岁),采用Mann-Whitney检验方法进行两组间各参数比较,采用Spearman相关法分析两组女性血清AMH水平与其它各参数间的关系.结果:高龄组血清FSH水平高于对照组,AMH、E2、P、T水平低于对照组(P＜0.01),两组间血清LH水平比较无差异(P＞0.05).两组血清AMH水平均与年龄、FSH呈负相关(P＜0.01),与P呈正相关(P＜0.05);对照组血清AMH水平与LH、T呈正相关(P＜0.01),与E2无相关性(P＞0.05);高龄组血清AMH水平与LH呈负相关,与E2呈正相关(P＜0.01),与T无相关性(P＞0.05).结论:女性随着年龄的增加血清中AMH水平进行性下降,AMH下降(30岁后开始)比FSH(38岁后开始)更早反映妇女生育能力的下降,年龄38～45岁血清AMH水平与FSH、LH、E2的相关性较23～37岁变化明显.%Objective:To explore the relationship between level of serum anti-mullerian hormone(AMH) and age or level of sex hormones of childbearing age women.Methods:In the retrospective study,dates of 719 childbearing age women from Guigang city people's hospital were collected,which included level of serum AMH,follicle stimulating hormone(FSH),luteinising hormone (LH),testosterone (T),estradiol (E),and progesterone (P).All recruited women were divided into two groups based on their age (from 38 to 45 years old in elder group,and from 23 to 37 years old in control group).The level of serum parameters of included women by the mann-whitney test were compared between the two groups.The relationship was analyzed by spearman rank correlation coefficient method between serum AMH and age or level of sex hormones of women in the two groups.Results:The level of serum FSH of women in elder group were significant higher than that of women in control group (P＜0.01),the level of AMH,E,P and T of women in elder group were significant lower than those of women in control group (P＜0.01),but there were no sig nificant different in the level of LH between the two groups(P＞0.05).The levels of serum AMH was negatively cor related with age and FSH(P＜0.01),and was positively associated with P(P＜0.05)in both groups.The level of serum AMH was positively associated with LH and T(P＜0.01),but was no significant correlation with E(P＞0.05)in control group.The level of serum AMH was negatively correlated with LH(P＜0.01),and was positively correlated with E(P＜0.01),but was no significant correlation with T(P＞0.05)in elder group.Conclusion:The level of serum AMH of women is gradually declined with age.The level of serum AMH decreasing (begins from 30 years old) can reflect the decline of female fertility early when compared to that the level of serum FSH (begins from 38 years old).The correlation between serum AMH and FSH,LH or E2 of women at 38-45 years old is more close than that of women in 23-37 years old.
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