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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >Vascular associated gene variants in patients with preeclampsia: Results from the Danish National Birth Cohort
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Vascular associated gene variants in patients with preeclampsia: Results from the Danish National Birth Cohort

机译：先兆子痫患者的血管相关基因变异：丹麦国家出生队列的结果

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摘要

Objective. Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms. Design. The study was a retrospective nested case-cohort design. Setting. Pregnant Danish women participating in the Danish National Birth Cohort. Population. 263 cases of severe preeclampsia and 1851 random controls were selected from the Danish National Birth Cohort. Methods. We validated all cases of severe preeclampsia and genotyped for 108 single nucleotide polymorphisms (SNPs) that were selected based on previous publications on the association with vascular disease. Logistic models were used for statistical analyses. Main outcome measures. Maternal polymorphisms in genomic models. Results. We found 17 of 108 SNPs associated with severe preeclampsia (p < 0.05). Women homozygous for the rs1799983 in NOS3 were 1.6-fold [95% confidence interval (CI) 1.0-2.4] more likely to develop severe preeclampsia. Women homozygous for the rs1010 SNP in VAMP8 were twofold (95%CI 1.1-3.5) more likely to deliver preterm when preeclampsia was present. Women homozygous for the rs10811661 SNP were 2.1-fold (95%CI 1.1-3.9) more likely to develop severe preeclampsia and 3.7-fold (95%CI 1.1-12.4) more likely to deliver a small-for-gestational age child when preeclampsia was present. All associations are available as Supporting Information. Conclusion. We found several vascular-associated SNPs linked to severe preeclampsia; however, most of these associations are probably by pure chance, which warrants replication and further translational research. To date, no specific SNP has yet proven valuable in a clinical setting in predicting preeclampsia.
机译：目的。子痫前期与随后的血管疾病有许多共同的诱发因素。我们调查了严重先兆子痫及其亚型与特定的血管相关多态性之间的关联。设计。该研究是回顾性嵌套病例队列设计。设置。参加丹麦国家出生队列的丹麦孕妇。人口。从丹麦国家出生队列中选择了263例严重子痫前期患者和1851例随机对照。方法。我们验证了所有先兆子痫的严重病例，并根据先前关于血管疾病的文献对108个单核苷酸多态性（SNP）进行了基因分型。逻辑模型用于统计分析。主要观察指标。基因组模型中的母体多态性。结果。我们发现108个SNP中有17个与严重先兆子痫相关（p <0.05）。在NOS3中纯合rs1799983的女性患严重子痫前期的可能性高1.6倍[95％置信区间（CI）1.0-2.4]。当存在先兆子痫时，在VAMP8中纯合rs1010 SNP的女性发生早产的可能性增加两倍（95％CI 1.1-3.5）。纯合子rs10811661 SNP的妇女发生严重子痫前期的可能性高2.1倍（95％CI 1.1-3.9），发生子痫前期的可能性高的妇女有3.7倍（95％CI 1.1-12.4）。存在。所有关联都可以作为支持信息。结论。我们发现了几种与严重子痫前期有关的与血管相关的SNPs。但是，这些关联中的大多数可能都是偶然的，因此有必要进行复制和进一步的翻译研究。迄今为止，尚无特定的SNP在预测先兆子痫的临床环境中有价值。

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