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首页> 外文期刊>Acta microbiologica et immunologica Hungarica: A quarterly of the Hungarian Academy of Sciences >Emergence of antiretroviral drug resistance in therapy-naive HIV infected patients in Hungary.
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Emergence of antiretroviral drug resistance in therapy-naive HIV infected patients in Hungary.

机译：在匈牙利，未接受过治疗的未感染HIV的患者出现了抗逆转录病毒药物耐药性。

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Mutations in the HIV-1 genes associated with resistance to antiretroviral drugs were detected also in primary HIV infected individuals who did not receive antiretroviral treatment. Drug resistance genotyping of HIV pol gene was done by in situ DNA hybridization using a Line Probe Assay and by direct sequencing. Viral variants harbouring resistance mutations such as: M41, T69R, K70R, M184V, T215Y in the pol gene were detected in 14% of the subjects. HIV mutants resistant to NRT inhibitors were found in 10 and 20% of patients infected before and after the year 2000, respectively. Multiple drug resistant viruses (2-3 drug classes) were present in 3.5% of the mainly recently infected patients. In protease gene only minor resistant mutations were found such as L101 and A71V. These findings indicate the evolution of drug resistance showing a correlation with the time of introduction of combination therapy in our country, where more than 70% of HIV infections were by homo/bisexual transmission. This confirms the transmission of drug-resistant HIV shown by genotype testing during primary infection in therapy-naive patients and initiates serious clinical and public health consequences.
机译：在未接受抗逆转录病毒治疗的原发性HIV感染患者中，也检测到与抗逆转录病毒药物抗性相关的HIV-1基因突变。 HIV pol基因的耐药基因分型是通过使用Line Probe Assay进行原位DNA杂交并通过直接测序完成的。在14％的受试者中检测到了pol基因中带有抗性突变的病毒变体，例如：M41，T69R，K70R，M184V，T215Y。在2000年之前和之后分别有10％和20％的患者感染了对NRT抑制剂具有抗性的HIV突变体。 3.5％的主要最近感染的患者中存在多种耐药病毒（2-3种药物类别）。在蛋白酶基因中，仅发现较小的抗性突变，例如L101和A71V。这些发现表明，耐药性的发展与我国引入联合疗法的时间有关，在中国，超过70％的HIV感染是通过同性恋/双性恋传播。这证实了未经基因治疗的患者在初次感染期间通过基因型测试显示的抗药性HIV的传播，并引发了严重的临床和公共卫生后果。

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