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首页> 外文期刊>Cortex: A Journal Devoted to the Study of the Nervous System and Behavior >Titrating the neuroplastic effects of cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex
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Titrating the neuroplastic effects of cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex

机译：滴定阴极经颅直流刺激（TDC）对初级运动皮层的神经塑性效果

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Transcranial direct current stimulation (tDCS) non-invasively induces polarity-dependent excitability alterations in the human motor cortex lasting for more than an hour after stimulation. Clinical applications with encouraging results have been reported in several pilot studies, but the optimal stimulation protocols remain to be determined. This is also important because the efficacy and directionality of tDCS effects follow non-linear rules regarding neuroplastic effects for the stimulation parameters duration and intensity. In this study, we systemically explored the association between tDCS, these parameters and induced after-effects on motor cortex excitability. Cathodal tDCS was applied in four different intensities (sham, 1, 2 and 3 mA) and three durations (15, 20 and 30 mins) in 16 young healthy subjects and the after-effects were monitored with TMS-induced motor evoked potentials (MEP) until the next day evening after stimulation. The results of the repeated measures ANOVA conducted to disentangle the effects of tDCS intensity and duration show a main effect of intensity in which 1 mA and 3 mA stimulation induced a reduction of MEP amplitudes, but 2 mA resulted in excitability enhancement. The results of a secondary ANOVA conducted to compare if active stimulation effects differ from those of sham stimulation revealed a significant main effect of tDCS condition in which 1 mA-15 min, 1 mA-30 min and 3 mA-20 min cathodal tDCS induced LTD-like plasticity, while LTP-like plasticity was observed after 2 mA-20 min stimulation. Our study thus provides further insights on the dependency of tDCS -induced neuroplasticity from the stimulation parameters, and therefore delivers crucial information for future applications. (C) 2019 Elsevier Ltd. All rights reserved.
机译：经颅直流刺激（TDCS）在刺激后持续超过一个小时的人机皮层中的非侵入性地诱导极性依赖性兴奋性改变。在几项试验研究中报告了令人鼓舞的结果的临床应用，但最佳刺激协议仍有待确定。这也很重要，因为TDCS效果的疗效和方向性遵循关于刺激参数持续时间和强度的神经塑性效果的非线性规则。在这项研究中，我们系统性地探索了TDC的关联，这些参数和对电机皮质兴奋性的诱导的后效应。阴极TDC应用于四种不同的强度（假，1,2和3 mA）和16个年轻健康受试者的三个持续时间（15,20和30分钟），并用TMS诱导的电动机诱发电位监测后效应（MEP ）直到刺激后的第二天晚上。反复措施Anova的结果进行解除TDCS强度和持续时间的影响表明，强度的主要效果，其中1 mA和3 mA刺激诱导了MEP振荡的减少，但是2mA导致兴奋性增强。进行的二级ANOVA的结果进行比较，如果有活性刺激效应与假刺激的刺激差异显示出TDCS条件的显着主要效果，其中1 mA-15分钟，1 mA-30分钟和3 mA-20分钟TDCS诱导有限公司 - 状可塑性，而在2mA-20分钟后观察到LTP样可塑性。因此，我们的研究进一步了解TDCS引起的神经塑性与刺激参数的依赖性的探讨，因此为未来的应用提供了重要信息。 （c）2019年elestvier有限公司保留所有权利。

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