Are we ready for a paradigm shift from high-dose conventional to moderate hypofractionated radiotherapy in intermediate-high risk prostate cancer? A systematic review of randomized controlled trials with trial sequential analysis

Ferella Letizia; Limoncin Erika; Vittorini Francesca; Chalaszczyk Agnieszka; Sorce Claudia; Grimaldi Gianmarco; Franzese Pietro; Ruggieri Valeria; Varrassi Emilia; Di Staso Mario; De Lorenzo Ramon Gimenez; Marampon Francesco; Tombolini Vincenzo; Masciocchi Carlo; Gravina Giovanni Luca

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Are we ready for a paradigm shift from high-dose conventional to moderate hypofractionated radiotherapy in intermediate-high risk prostate cancer? A systematic review of randomized controlled trials with trial sequential analysis

机译：我们是否准备好从高剂量常规转移到中度风险前列腺癌中等高次次次次次级放射疗法？试验顺序分析对随机对照试验的系统综述

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摘要

Aim: to evaluate efficacy and late toxicity of moderate hypofractionated (HFRT) over high-dose (>= 76 Gy) conventional radiotherapy (CRT) in a non-inferiority perspective.

机译：目的：以非劣级度的观点评估高剂量（> = 76GY）常规放射治疗（CRT）的中度低次级（HFRT）的疗效和晚期毒性。

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来源
《Critical reviews in oncology/hematology》 |2019年第2019期|共8页
作者
Ferella Letizia; Limoncin Erika; Vittorini Francesca; Chalaszczyk Agnieszka; Sorce Claudia; Grimaldi Gianmarco; Franzese Pietro; Ruggieri Valeria; Varrassi Emilia; Di Staso Mario; De Lorenzo Ramon Gimenez; Marampon Francesco; Tombolini Vincenzo; Masciocchi Carlo; Gravina Giovanni Luca;
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作者单位

Hospistal Aosta Radiat Oncol ThomoTherapy Unit Aosta Italy;

Univ Tor Vergata Dept Syst Med Rome Italy;

Univ Aquila Serv Med Phys Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

Univ Aquila Serv Med Phys Laquila Italy;

Univ Roma La Sapienza Div Radiotherapy Rome Italy;

Univ Roma La Sapienza Div Radiotherapy Rome Italy;

Univ Aquila Div Radiol Laquila Italy;

Univ Aquila Div Radiotherapy Laquila Italy;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Prostate cancer; Hypofractionated radiotherapy; Systematic review; Metanalysis; Non-inferiority;

机译：前列腺癌;低次级放射治疗;系统评价;元分析;非劣等;

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外文文献

1. Are we ready for a paradigm shift from high-dose conventional to moderate hypofractionated radiotherapy in intermediate-high risk prostate cancer? A systematic review of randomized controlled trials with trial sequential analysis [J] . Ferella Letizia, Limoncin Erika, Vittorini Francesca, Critical reviews in oncology/hematology . 2019,第期

机译：我们是否准备好从高剂量常规转移到中度风险前列腺癌中等高次次次次次级放射疗法？试验顺序分析对随机对照试验的系统综述
2. Hypofractionated radiotherapy versus conventional radiotherapy in patients with intermediate- to high-risk localized prostate cancer: a meta-analysis of randomized controlled trials [J] . Wei Guo, Yun-Chuan Sun, Jian-Qiang Bi, BMC Cancer . 2019,第1期

机译：中间至高风险局部前列腺癌患者的低次分配放射治疗：随机对照试验的荟萃分析
3. Patient Reported Acute Toxicity in PACE-B, an International Phase III Randomised Controlled Trial Comparing Stereotactic Body Radiotherapy to Conventionally Fractionated or Moderately Hypofractionated Radiotherapy (CFMHRT) for Localised Prostate Cancer [J] . Brand D. H., Tree A., Ostler P., International Journal of Radiation Oncology, Biology, Physics . 2019,第1Suppla期

机译：患者报告了Pace-B中的急性毒性，将局部前列腺体放射治疗的国际阶段III随机对照试验比较局部前列腺癌（CFMHRT）对比较的立体定向体放射治疗
4. Stroke unit of integrative medicine for post stroke comorbid anxiety and depression: A systematic review and meta-analysis of 25 randomized controlled trials [C] . Lingfeng Zeng, Changrong Meng, Zhaohui Liang, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：中风后合并焦虑和抑郁的中西医结合卒中科：25项随机对照试验的系统评价和荟萃分析
5. Predictive Biomarkers of the Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Treating Advanced Non-small Cell Lung Cancer: A Systematic Review of Randomized Controlled Trials [D] . Yang, Zuyao. 2014

机译：表皮生长因子受体酪氨酸激酶抑制剂治疗晚期非小细胞肺癌疗效的预测生物标志物：随机对照试验的系统评价。
6. Moderate hypofractionated radiotherapy vs conventional fractionated radiotherapy in localized prostate cancer: a systemic review and meta-analysis from Phase III randomized trials [O] . Zhenzhen Yin, Jinqiang You, Youyou Wang, 2019

机译：局部前列腺癌的中度超分割放疗与常规分割放疗：III期随机试验的系统评价和荟萃分析
7. Hypofractionated radiotherapy versus conventional radiotherapy in patients with intermediate- to high-risk localized prostate cancer: a meta-analysis of randomized controlled trials [O] . Wei Guo, Yun-Chuan Sun, Jian-Qiang Bi, 2019

机译：中间至高风险局部前列腺癌患者的低次分配放射治疗：随机对照试验的荟萃分析

Are we ready for a paradigm shift from high-dose conventional to moderate hypofractionated radiotherapy in intermediate-high risk prostate cancer? A systematic review of randomized controlled trials with trial sequential analysis

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