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首页> 外文期刊>Critical Reviews in Biomedical Engineering >The Virtual Microbiome: Computational Approaches to the Study of Microbe-Host Interactions
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The Virtual Microbiome: Computational Approaches to the Study of Microbe-Host Interactions

机译：虚拟微生物组：微生物主机交互研究的计算方法

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摘要

The GI tract of a normal adult human contains on the order of 10(14) foreign living organisms, collectively known as the gut microbiome, the proper maintenance of which is critical for health. Because the gut microbiome is a dynamic system of vast complexity, computational modeling is assuming an increasingly important role in helping us to understand how and why it behaves as it does. In particular, computational models can serve as a rapid, cost-effective means of simulating the microbiome on multiple scales, from that of an individual bacterium to the microbiome as a whole. This not only allows questions to be addressed in ways that are impractical in the experimental laboratory; it also permits competing hypotheses to be interrogated for feasibility before they are subjected to expensive and time-consuming experimental testing. Here we review some of the differential equation-based and agent-based approaches that have been applied to the computational modeling of the gut microbiome and its effects on the rest of the body. The models discussed are helping us understand how the microbiome works as a system, how it maintains its crucial symbiotic relationship with its host, and, in particular, how its malfunctions can lead to a number of important and often serious pathologies.
机译：正常成人人的GI含量大约10（14）个异物生物，统称为肠道微生物组，适当的维护对健康至关重要。因为肠道微生物组是一种巨大复杂性的动态系统，所以计算建模是假设有助于我们了解如何以及为什么它表现得越来越重要。特别地，计算模型可以作为在多个尺度上模拟微生物的微生物组的快速成本效益的方法，从单独的细菌到整体上的微生物组。这不仅允许以实验实验室在实验性不切实际的方式解决的问题;它还允许竞争假设在经历昂贵且耗时的实验测试之前被审查以进行可行性。在这里，我们回顾了已经应用于肠道微生物组的计算建模的一些基于方程式和基于代理的方法以及其对身体其余部分的影响。讨论的模型正在帮助我们了解Microbiome如何作为系统，如何与其主持人保持其至关重要的共生关系，特别是其故障如何导致许多重要和往往严重的病理学。

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