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首页> 外文期刊>Cornea >Corneal Light Scatter After Ultrathin Descemet Stripping Automated Endothelial Keratoplasty Versus Descemet Membrane Endothelial Keratoplasty in Descemet Endothelial Thickness Comparison Trial: A Randomized Controlled Trial
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Corneal Light Scatter After Ultrathin Descemet Stripping Automated Endothelial Keratoplasty Versus Descemet Membrane Endothelial Keratoplasty in Descemet Endothelial Thickness Comparison Trial: A Randomized Controlled Trial

机译：超薄剥离剥离自动内皮角膜术与去皮膜内皮角膜术中的角膜光散射在DesCemet内皮厚度比较试验中：随机对照试验

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Purpose: To compare the degree of corneal light scatter as measured by densitometry in ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) and Descemet Membrane Endothelial Keratoplasty (DMEK) in the Descemet endothelial thickness comparison trial. Methods: This was a prespecified secondary analysis of the Descemet endothelial thickness comparison trial, which was a prospective, randomized controlled trial. Subjects with isolated endothelial dysfunction were enrolled and were randomized to either UT-DSAEK or DMEK. Corneal opacity was quantitatively measured by Pentacam densitometry (OCULUS) at 3, 6, and 12 months. Results: Fifty eyes of 38 patients were enrolled at the Casey Eye Institute at Oregon Health & Science University and the Byers Eye Institute at Stanford University. Corneal densitometry for the anterior and posterior layers improved in both UT-DSAEK and DMEK after surgery. The decrease was more pronounced in the posterior layer for both groups. However, there was no difference in the degree of corneal light scatter between UT-DSAEK and DMEK at postoperative month 12, and no difference in change in densitometry was observed between the 2 arms from baseline to month 12. Conclusions: Both UT-DSAEK and DMEK experience an improvement in the degree of corneal light scatter after surgery. However, there was no difference in densitometry between the 2 groups at month 12. Therefore, other factors such as higher order aberrations in the posterior cornea rather than stromal-stromal interface haze mediate the superior visual outcomes in DMEK compared with UT-DSAEK.
机译：目的：将通过密度测量测量的超薄DESCEMET剥离自动内皮角膜形术（UT-DSAEK）和DESCET膜内皮角膜术（DMEK）进行比较角膜光散射的程度。方法：这是对Desceemet内皮厚度比较试验的预先确定的二次分析，是一种预期的随机对照试验。注册了具有分离内皮功能障碍的受试者，并随机随机化为UT-DSAEK或DMEK。在3,6和12个月的戊克蛋白密度测定法（Oculus）定量测量角膜不透明度。结果：在俄勒冈州卫生与科学大学凯西眼学院和斯坦福大学守界学院的凯西眼学院患有58名患者的五十眼。手术后UT-DSAEK和DMEK的前部和后层的角膜密度测定法。两个组的后层中的减少更加明显。然而，在术后第12个月12的UT-dsaek和DMEK之间的角膜光程度散射没有差异，并且在从基线到第12个武器之间观察到密度测量变化的变化差异。结论：ut-dsaek和DMEK在手术后的角膜光散射程度的改善。然而，在12月12日之间的2组之间的密度测定法没有差异。因此，与UT-DSAEK相比，后角膜中的其他因素如后角膜中的更高阶畸变，而不是基质 - 基质界面雾霾。

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