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Adjuvant Use of Cyclosporine A in the Treatment of Primary Pterygium: A Systematic Review and Meta-Analysis

机译：辅助使用环孢菌素A治疗原发性翼状胬肉：系统评价和荟萃分析

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摘要

Purpose:To evaluate the efficacy and tolerability of cyclosporine A (CsA) as an adjuvant treatment for primary pterygium.Methods:A comprehensive literature search from 7 databases (EMBASE, ISI Web of Science, PubMed, and the Cochrane Library for studies published in English and VIP, Wan Fang, and CNKI for studies published in Chinese). For the recurrence rate, pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. Tolerability estimates were measured by OR for adverse events.Results:A total of 7 studies meeting the inclusion criteria were included in this meta-analysis. Compared with the group with adjunctive CsA usage, the control group (no adjuvant use of CsA) showed a significantly increased risk of pterygium recurrence (OR = 2.71; 95% CI, 1.62-4.54). No obvious heterogeneity was detected in the included studies. Subgroup analysis showed that adjuvant use of CsA with pterygium excision alone resulted in a significantly lower frequency of recurrence than was seen in the group without adjuvant use of CsA (OR = 3.16; 95% CI, 1.18-8.84). However, there is no significant difference in pterygium recurrence between the subgroup (CsA + pterygium excision + limbal conjunctival autograft or flap rotation) and the subgroup without adjunctive CsA usage (pterygium excision + limbal conjunctival autograft or flap rotation).Conclusions:This meta-analysis suggests that adjuvant use of CsA can significantly reduce the risk of pterygium recurrence compared with pterygium excision alone, whereas adjuvant use of CsA may not reduce the risk of pterygium recurrence in terms of pterygium excision + limbal conjunctival autograft or conjunctival flap rotation.
机译：目的：评估环孢菌素A（CSA）作为原发性翼序的佐剂治疗的疗效和耐受性。方法：从7个数据库（Embase，Isi Web，Pubmed和Cochrane图书馆进行英语，综合文献搜索和VIP，WAN Fang和CNKI在中文发布的研究）。对于复发率，使用随机效应模型计算汇集的差距（或）和95％置信区间（CI）。可耐受性估计由不利事件或不利的事件来衡量。结果：在该荟萃分析中包含符合纳入标准的7项研究。与具有辅助CSA使用的组相比，对照组（CSA的佐剂使用）显示出翼状胬肉复发的风险显着增加（或= 2.71; 95％CI，1.62-4.54）。在包括的研究中没有检测到明显的异质性。亚组分析表明，单独使用翼状胬肉切除的CSA的佐剂使用比在本组中看到的复发频率明显较低，而不会佐速使用CSA（或= 3.16; 95％CI，1.18-8.84）。然而，亚组（CSA +翼状胬肉切除+斜坡自体移植物或翻盖）和亚组之间的翼组复发没有显着差异，没有辅助CSA使用（翼状胬肉切除+斜坡自体移植物或翻转旋转）.Conclusions：这个元分析表明，与单独的翼状胬肉切除相比，CSA的辅助使用CSA可以显着降低翼状胬肉复发的风险，而CSA的佐剂使用可能不会降低翼状胬肉切除+斜峰结膜自体移植或结膜皮瓣旋转方面的翼状胬肉复发的风险。

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  • 来源
    《Cornea》 |2018年第8期|共8页
  • 作者

    Zhang Qing; Bao Ning; Liang Kun; Tao Liming;

  • 作者单位

    Anhui Med Univ Hosp 2 Dept Ophthalmol 678S Furong Rd Hefei 230601 Anhui Peoples R China;

    Anhui Med Univ Hosp 2 Dept Ophthalmol 678S Furong Rd Hefei 230601 Anhui Peoples R China;

    Anhui Med Univ Hosp 2 Dept Ophthalmol 678S Furong Rd Hefei 230601 Anhui Peoples R China;

    Anhui Med Univ Hosp 2 Dept Ophthalmol 678S Furong Rd Hefei 230601 Anhui Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 眼科学;
  • 关键词

    pterygium; cyclosporine A; recurrence; meta-analysis;

    机译：翼状胬肉;环孢菌素A;复发;荟萃分析;

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