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首页> 外文期刊>Cornea >Long-term Progression of Ocular Surface Disease in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
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Long-term Progression of Ocular Surface Disease in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

机译：史蒂文森约翰逊综合征和有毒表皮症中眼表面疾病的长期进展

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Purpose: To investigate the details of the long-term progression of ocular surface cicatrization in eyes with ocular sequelae caused by Stevens-Johnson syndrome (SJS)/toxic epidermal necrosis (TEN). Methods: In 105 eyes of 66 patients with SJS/TEN, the severity of ocular sequelae was retrospectively evaluated using an ocular surface grading score (OSGS) at 2 time points separated by a greater than 5-year interval. The OSGS included 7 ocular surface components (conjunctivalization, neovascularization, opacification, keratinization, symblepharon, and upper/lower conjunctival-sac shortening) evaluated into grades 0 to 3 (maximum total OSGS: 21), with the worsening of each component and total OSGS evaluated at the greater than 5-year interval. Moreover, we evaluated whether upper-tarsus and lid-margin scarring are factors that affect ocular surface cicatrization progression. Results: In 35 (33.3%) of 105 eyes, the total OSGS worsened during the follow-up period. Partial conjunctivalization (score 1-2) progressed more frequently to total conjunctivalization (score 3) than to no conjunctivalization (score 0) (OR [95% CI]; 5.6 [1.6-20.3]). Partial keratinization (score 1-2) also had a high risk of progression into total keratinization (41.0 [6.3-266.5]). In all cases, keratinization progressed only in the eyes with total conjunctivalization (conjunctivalization score 3). Severity of upper-tarsus scarring or lid-margin scarring affected the worsening of the total OSGS. Conclusions: In 66 patients with chronic-phase SJS/TEN, ocular surface cicatrization progressed in 33.3% of the 105 eyes during the long-term follow-up period of over 5 years. More than 50% of the partial conjunctivalization eyes progressed toward total conjunctivalization. The partial keratinization eyes had a high possibility of progressing to total keratinization; that is, the so-called "end-stage" status.
机译：目的：探讨眼睛后遗症引起的眼睛后遗症患者眼睛的长期进展细节，由史蒂文森 - 约翰逊综合征（SJS）/毒性表皮坏死（十）。方法：在66例SJS / 10患者105只眼中，在2个时间点以大于5年间隔的2个时间点，回顾性地评估眼睛表面的严重程度。 OSGS包括7种眼表面组分（结膜，新血管，透明度，角质化，搅拌乳酮和上层结膜 - 缩短）评估为0至3级（最大总OSG：21），其每种组分恶化和总OSGS以大于5年的间隔评估。此外，我们评估了上tarsus和盖子保证金疤痕是否为影响眼表面瘢痕化进展的因素。结果：35只（33.3％）105只（33.3％），在随访期间，总OSG均匀。部分结膜（分数1-2）更频繁地进入总结膜（得分3），而不是没有结膜（得分0）（或[95％CI]; 5.6 [1.6-20.3]）。部分角化化（得分1-2）也具有高进化的进展风险，进入全角质化（41.0 [6.3-266.5]）。在所有情况下，角蛋白化只能在眼中进行，总结合（结膜得分3）。疤痕疤痕的严重程度或盖子保证金疤痕影响了总OSG的恶化。结论：在66例慢性期SJS / 10患者中，在长期随访期内，在105只眼中的33.3％中进展了33.3％。超过50％的部分结膜眼睛朝向总结合化。部分角质化眼睛具有高可能进展到全角质化的可能性;也就是说，所谓的“终级”状态。

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