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首页> 外文期刊>Acta microbiologica et immunologica Hungarica: A quarterly of the Hungarian Academy of Sciences >Regularities and irregularities in the cell cycle of the fission yeast, Schizosaccharomyces pombe (a review).
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Regularities and irregularities in the cell cycle of the fission yeast, Schizosaccharomyces pombe (a review).

机译：裂殖酵母粟酒裂殖酵母的细胞周期中的规律性和不规则性（综述）。

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摘要

In an exponentially growing wild-type fission yeast culture a size control mechanism ensures that mitosis is executed only if the cells have reached a critical size. However, there is some scattering both in cell length at birth (BL) and in cycle time (CT). By computational simulations we show here that this scattering cannot be explained solely by asymmetric cell division, therefore we assume that nuclear division is a stochastic, asymmetric process as well. We introduce an appropriate stochastic variable into a mathematical model and prove that this assumption is suitable to describe the CT vs. BL graph in a wild-type fission yeast population. In a double mutant of fission yeast (namely wee1-50 cdc25 delta) this CT vs. BL plot is even more curious: cycle time splits into three different values resulting in three clusters in this coordinate system. We show here that it is possible to describe these quantized cycles by choosing the appropriate values of the key parameters of mitotic entry and exit and even more the clustered behavior may be simulated by applying a further stochastic parameter.
机译：在指数增长的野生型裂变酵母培养物中，尺寸控制机制可确保仅在细胞达到临界尺寸时才进行有丝分裂。但是，出生时的细胞长度（BL）和周期时间（CT）都有一些散射。通过计算仿真，我们在这里表明，不能仅通过不对称细胞分裂来解释这种散射，因此我们假定核分裂也是随机的，不对称的过程。我们将适当的随机变量引入数学模型，并证明此假设适合描述野生型裂变酵母种群中的CT与BL图。在裂变酵母的双突变体（即wee1-50 cdc25 delta）中，这个CT与BL的关系图更加奇怪：循环时间分为三个不同的值，从而在该坐标系中形成三个簇。我们在这里表明，可以通过选择有丝分裂进入和退出的关键参数的适当值来描述这些量化的周期，并且甚至可以通过应用其他随机参数来模拟群集行为。

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