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首页> 外文期刊>Acta Biochimica Polonica >Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies
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Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies

机译：三萜皂苷对癌细胞的多方向作用-体外研究综述

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摘要

Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 mu M) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.
机译：三萜皂苷（皂苷）存在于多种高等植物中，并显示出广泛的药理活性，包括祛痰，抗炎，血管保护，胃保护和抗菌特性。最近，已经提出了皂苷的潜在的抗癌活性，其具有细胞毒性，抑制细胞生长，促凋亡和抗侵袭的作用。在高浓度（超过100μM）下，皂苷通过细胞膜的透化作用发挥细胞毒性和溶血作用。值得注意的是，在低皂苷浓度下观察到了癌细胞增殖的抑制，凋亡的诱导和细胞侵袭力的减弱。皂苷可能会影响与恶性肿瘤相关的基因的表达。这些改变与癌细胞的侵袭表型直接相关，并取决于“细胞背景”。它说明了皂苷的作用与癌细胞的瞬时基因组/蛋白质组学状态之间的关系。在这里，我们讨论皂角苷抗癌活性的特点，特别着重于已与肿瘤治疗相关的各种皂苷群的抗侵袭作用。

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