Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer

Linkowska Katarzyna; Jawien Arkadiusz; Marszalek Andrzej; Skonieczna Katarzyna; Grzybowski Tomasz

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Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer

机译：寻找线粒体DNA聚合酶γ基因（POLG）中CAG重复多态性与结直肠癌的关联

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Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.

机译：线粒体DNA聚合酶γ（POLG）是唯一参与维持线粒体基因组的DNA聚合酶。最近的研究表明，POLG基因第二个外显子中CAG重复多态性与癌症风险相关。我们调查了来自结直肠癌患者的肿瘤和非肿瘤组织以及从年龄匹配的健康人血液中分离的DNA样本中的POLG基因中CAG重复变异性。在10％的患者中观察到了癌组织中体细胞发生的CAG重复改变，但在POLG基因中的CAG重复变异与大肠癌风险之间未发现关联。

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来源
《Acta Biochimica Polonica》 |2015年第3期|共3页
作者
Linkowska Katarzyna; Jawien Arkadiusz; Marszalek Andrzej; Skonieczna Katarzyna; Grzybowski Tomasz;
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正文语种 eng
中图分类生物化学;
关键词
POLG gene; CAG repeat; colorectal cancer; somatic mutations;

机译：POLG基因;CAG重复;大肠癌;体细胞突变;

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1. Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer [J] . Linkowska Katarzyna, Jawien Arkadiusz, Marszalek Andrzej, Acta Biochimica Polonica . 2015,第3期

机译：寻找线粒体DNA聚合酶γ基因（POLG）中CAG重复多态性与结直肠癌的关联
2. Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. [J] . Blomberg-Jensen M, Leffers H, Petersen JH, Annals of oncology: official journal of the European Society for Medical Oncology . 2008,第11期

机译：线粒体DNA聚合酶γ基因（POLG）中CAG重复序列的多态性与睾丸生殖细胞癌的关联。
3. Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer [J] . M. Blomberg Jensen1 H. Leffers1 J. H. Petersen12 G. Daugaard3 N. E. Skakkebaek1 and E. Rajpert-De Meyts1 Annals of Oncology . 2008,第11期

机译：线粒体DNA聚合酶γ基因（POLG）中CAG重复序列的多态性与睾丸生殖细胞癌的关系
4. Associations between Lung Cancer Risk and Polymorphisms in the DNA Repair Genes X-ray Repair Cross-complementing Group 1(XRCC1) [C] . YIN Li-hong, PU Yue-pu, SONG Ya-hui International Academic Conference on Environmeatal amp; Occupational Medicine; 20041110-12; Shanghai(CN) . 2004

机译：DNA修复基因X射线修复交叉互补组1（XRCC1）中肺癌风险与多态性之间的关联
5. The associations between diet, flavonoids, polymorphisms of the PPAR-gamma, PPAR-delta, and CRP genes and lung and upper aerodigestive tract (UADT) cancers [D] . Burke, Rita Velikina. 2008

机译：饮食，类黄酮，PPAR-γ，PPAR-δ和CRP基因多态性与肺癌和上消化道消化道（UADT）癌症之间的关联
6. CAG Repeat Variants in the POLG1 Gene Encoding mtDNA Polymerase-Gamma and Risk of Breast Cancer in African-American Women [O] . Sami Azrak, Vanniarajan Ayyasamy, Gary Zirpoli, 2009

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7. CAG repeat variants in the POLG1 gene encoding mtDNA polymerase-gamma and risk of breast cancer in African-American women [O] . Azrak S, Ayyasamy V, Zirpoli G, 2012

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8. Epidermal Growth Factor (EGF) Receptor Intron 1 CA Repeat Polymorphisms in African-American and Caucasian Males: Influence on Prostate Cancer Risk or Disease Progression and Interaction with Androgen Receptor CAG Repeat Polymorphisms [R] . Moscatello, D. K. 2005

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Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer

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