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Lessons learned from recent clinical trials of ketogenic diet therapies in adults

机译：从最近的成人酮饮食疗法临床试验中了解的经验教训

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Purpose of review Although ketogenic diet therapies (KDTs) were first developed as a treatment for patients with epilepsy, their potential efficacy for a broader number of neurologic and nonneurologic disorders and conditions has been explored over the last 10-20 years. The most recent clinical trials of KDTs in adults have highlighted common methodological aspects that can either facilitate or thwart appropriate risk/benefit analyses, comparisons across studies, and reproducibility of findings in future studies. Recent findings Recent evidence suggests that KDTs not only improve seizure control, but also improve other neurologic conditions, including nonmotor Parkinson's disease symptoms. Therapies targeting nutritional ketosis without comprehensive diet modification improve cognition and cerebral blood flow in Alzheimer's disease patients. KDTs lower hemoglobin A1c levels and diabetes medication use in patients with Type 2 diabetes and mixed results have been observed when used for performance enhancement in athletes and healthy volunteers. Clinical studies of KDTs show promise for a variety of clinical indications. Future studies should factor in high potential participant attrition rates and utilize consistent and standard reporting of diet type(s), compliance measures, and side-effects to enable the reproducibility and generalizability of study outcomes.
机译：审查目的尽管酮饮食疗法（KDTS）首先是作为癫痫患者的治疗，但在过去10-20年内，他们对更广泛数量的神经系统和非暴力学疾病和病症的潜在疗效得到了潜在的疗效。成人KDTS最新临床试验强调了常见的方法论方面，可以促进或挫败适当的风险/益处分析，跨研究的比较以及未来研究中的调查结果的再现性。最近的结果最近的证据表明，KDTS不仅改善癫痫症，而且还改善了其他神经系统病症，包括非帕金森病症状。靶向营养睾酮的疗法没有综合饮食改性，提高了阿尔茨海默病患者的认知和脑血流量。 KDTS低层血红蛋白A1C水平和糖尿病药物用作2型糖尿病和混合结果的患者，当时用于运动员和健康志愿者的性能增强。 KDTS临床研究显示各种临床适应症的承诺。未来的研究应考虑到高潜在的参与者的磨损率，并利用饮食类型，合规措施和副作用的一致和标准报告，以实现研究结果的再现性和普遍性。

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