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New findings of oxidative stress biomarkers in nutritional research

机译：营养研究中氧化应激生物标志物的新发现

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Purpose of reviewThe aim of this article is to present a brief overview of recently published articles assessing oxidative stress markers in nutritional studies.Recent findingsIntervention and observational studies were carried out in both, healthy subjects and patients and describe the association of foodstuffs as well as isolated nutrients with biomarkers of oxidative stress. The results from human intervention studies on healthy participants and patients are controversial. Long-term interventions (>8 weeks) seem to be more effective than short-term or single-dose interventions. Results are difficult to compare because not only the methods used, also the assessed biomarkers and outcomes were very diverse. In addition, studies vary in the compounds and doses used, duration, participants and so on. Different biomarkers (damaged molecules together with antioxidants from different compartments) should be assessed to evaluate the true 'redox-status' of an individual and the impact of a nutritional intervention.SummaryBoth observational and interventional studies performed in healthy participants and patients show possible beneficial effects of nutrients and foodstuffs by improving oxidative stress markers and antioxidant enzyme activities. Biomarkers should be standardized to allow better comparison of results of antioxidant intervention studies.
机译：审查本文的目的是概述最近公布的文章，评估了营养研究中的氧化应激标志物。在健康受试者和患者中进行了治疗，并描述了食品和孤立的协会具有氧化胁迫的生物标志物的营养素。人类干预研究对健康参与者和患者的结果是有争议的。长期干预措施（> 8周）似乎比短期或单剂量干预更有效。结果难以比较，因为不仅使用的方法，也是评估的生物标志物和结果也非常多样化。此外，研究在化合物和剂量，持续时间，参与者等方面变化。应评估不同的生物标志物（损坏分子与来自不同隔间的抗氧化剂），以评估个体的真实“氧化还原状态”和营养干预的影响。在健康参与者和患者中进行的观测和介入研究表明可能的有益效果通过改善氧化应激标记物和抗氧化酶活性来营养和食品。生物标志物应标准化，以便更好地比较抗氧化干预研究的结果。

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