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首页> 外文期刊>Acta Biochimica Polonica >Proteomics in studies of Staphylococcus aureus virulence
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Proteomics in studies of Staphylococcus aureus virulence

机译：蛋白质组学在金黄色葡萄球菌毒力研究中

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摘要

Staphylococcus aureus is a widespread, opportunistic pathogen that causes community and hospital acquired infections. Its high pathogenicity is driven by multifactorial and complex mechanisms determined by the ability of the bacterium to express a wide variety of virulence factors. The proteome secreted into extracellular milieu is a rich reservoir of such factors which include mainly nonenzymatic toxins and enzymes. Simultaneously, membrane proteins, membrane-cell wall interface proteins and cell wall-associated proteins also strongly influence staphylococcal virulence. Proteomics shows a great potential in exploring the role of the extracellular proteome in cell physiology, including the pathogenic potential of particular strains of staphylococci. In turn, understanding the bacterial physiology including the interconnections of particular factors within the extracellular proteomes is a key to the development of the ever needed, novel antibacterial strategies. Here, we briefly overview the latest applications of gel-based and gel-free proteomic techniques in the identification of the virulence factors within S. aureus secretome and surfacome. Such studies are of utmost importance in understanding the host-pathogen interactions, analysis of the role of staphylococcal regulatory systems and also the detection of posttranslational modifications emerging as important modifiers of the infection process.
机译：金黄色葡萄球菌是一种广泛的机会病原体，可引起社区和医院获得性感染。其高致病性是由细菌表达多种毒力因子的能力决定的多因素和复杂机制驱动的。分泌到细胞外环境中的蛋白质组是这类因子的丰富库，这些因子主要包括非酶毒素和酶。同时，膜蛋白，膜-细胞壁界面蛋白和细胞壁相关蛋白也强烈影响葡萄球菌的毒力。蛋白质组学在探索细胞外蛋白质组在细胞生理学中的作用方面显示出巨大的潜力，包括某些葡萄球菌菌株的致病潜力。反过来，了解细菌生理学，包括细胞外蛋白质组内特定因素的相互联系，是开发不断需要的新颖抗菌策略的关键。在这里，我们简要概述了基于凝胶和无凝胶的蛋白质组学技术在金黄色葡萄球菌分泌蛋白组和​​surfacome的致病因子鉴定中的最新应用。此类研究对于理解宿主与病原体的相互作用，分析葡萄球菌调节系统的作用以及发现翻译后修饰（作为感染过程的重要修饰剂）至关重要。

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