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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Exclusive enteral nutrition for inducing remission in inflammatory bowel disease in paediatric patients
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Exclusive enteral nutrition for inducing remission in inflammatory bowel disease in paediatric patients

机译：专属肠内营养诱导儿科患者炎症性肠病中的缓解

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Purpose of review Enteral nutrition as a treatment for inflammatory bowel diseases is an ongoing area of interest. Even in the era of biologic agents, exclusive enteral nutrition (EEN) offers a unique, drug-free measure for induction of remission in luminal Crohn's disease. The purpose of this review is to discuss the role of EEN in the evolving therapeutic scheme for Crohn's disease, to report on new evidence for short and long-term efficacy and highlight findings on the mechanisms of the anti-inflammatory effects of EEN in light of current understanding of disease pathogenesis. Recent findings Recent clinical studies have suggested that EEN has an established advantage over corticosteroids for inducing remission in children with luminal Crohn's disease with comparable clinical efficacy but superior mucosal healing effect as well as better safety profile. Preoperative EEN therapy can also improve postoperative outcome of intestinal resection. Basic research has demonstrated that EEN has direct anti-inflammatory properties, can correct localization of tight junction proteins, alter micro RNAs expression, and profoundly affect the intestinal microbiota. Summary EEN is an effective treatment for induction of remission in pediatric luminal Crohn's disease and should be offered as a first-line treatment. Accumulating evidence suggest that EEN has direct anti-inflammatory properties with an effect on the intestinal microbiota. However, the relationships between these effects and the specific triggers for these changes have yet to be elucidated.
机译：审查肠内营养作为炎症性肠病的治疗目的是持续的兴趣领域。即使在生物制剂时代，独家肠内营养（EEN）也为诱导腔克罗恩病中的缓解诱导的独特无毒的措施。本综述的目的是讨论ZEN在克罗恩病的不断变化的治疗方案中的作用，报告短期和长期疗效的新证据，并强调了鉴于青色抗炎作用的机制目前对疾病发病机制的认识。最近的发现最近的临床研究表明，EEN在皮质类固醇中具有成熟的优势，用于诱导腔克罗恩病患者的儿童免疫性，具有可比的临床疗效，但优异的粘膜愈合效果以及更好的安全性。术前艾恩治疗还可以改善肠道切除术后的术后结果。基础研究表明，州具有直接的抗炎特性，可以纠正狭窄的结蛋白的定位，改变微rnas表达，并深刻影响肠道微生物。摘要Een是对儿科腔克罗恩病中缓解缓解的有效治疗方法，应作为一线治疗提供。累积证据表明，浓度具有直接的抗炎性能，对肠道微生物群产生影响。然而，这些效果与这些变化的特定触发之间的关系尚未得到阐明。

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