Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates

Hideyuki Okano; Noriyuki Kishi

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Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates

机译：基因改性非人类激励脑科学和神经学/精神疾病的调查

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Although mice have been the most frequently used experimental animals in many research fields due to well-established gene manipulation techniques, recent evidence has revealed that rodent models do not always recapitulate pathophysiology of human neurological and psychiatric diseases due to the differences between humans and rodents. The recent developments in gene manipulation of non-human primate have been attracting much attention in the biomedical research field, because non-human primates have more applicable brain structure and function than rodents. In this review, we summarize recent progress on genetically-modified non-human primates including transgenic and knockout animals using genome editing technology.

机译：虽然小鼠由于良好的基因操纵技术而在许多研究领域中是最常用的实验动物，但最近的证据表明，由于人和啮齿动物之间的差异，啮齿动物模型并不总是重新概括人类神经系统和精神病疾病的病理生理学。最近的基因操纵非人类灵长类动物的发展已经在生物医学研究领域引起了很多关注，因为非人类灵长类动物具有比啮齿动物更适用的大脑结构和功能。在本文中，我们总结了使用基因组编辑技术的转基因和敲除动物的遗传修饰的非人印象的最新进展。

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《Current Opinion in Neurobiology》 |2018年第2018期|共6页
作者
Hideyuki Okano; Noriyuki Kishi;
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Laboratory for Marmoset Neural Architecture RIKEN Brain Science Institute;

Laboratory for Marmoset Neural Architecture RIKEN Brain Science Institute;

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正文语种 eng
中图分类神经病学;
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1. Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates [J] . Hideyuki Okano, Noriyuki Kishi Current Opinion in Neurobiology . 2018,第期

机译：基因改性非人类激励脑科学和神经学/精神疾病的调查
2. Generation of genetically engineered non‐human primate models of brain function and neurological disorders [J] . Park Jung Eun, Silva Afonso C. American journal of primatology . 2019,第2期

机译：脑功能和神经疾病的转基因非人类灵长类会模型
3. Tedis: a collaborative information system to collect pertinent data from psychiatric, neurologic, and genetic investigations in patients with pervasive developmental disorder [J] . Robel L., Bensaid M., Damville E., European child & adolescent psychiatry . 2015,第Suppla1期

机译：Tedis：一个协作信息系统，用于从广泛性发育障碍患者的精神病学，神经病学和遗传学研究中收集相关数据
4. Basal Ganglia and Behaviour: Behavioural Effects of Deep Brain Stimulation in Experimental Neurological and Psychiatric Disorders [C] . Thibaut Sesia, Sonny Tan, Rinske Vlamings, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：基础神经节和行为：实验神经和精神病患者深脑刺激的行为影响
5. Oxidative Stress and Proteomic Studies of Mammalian Models of Age-Related Metabolic Dysfunction in Neurodegenerative Disorders: (1) Upregulation of Pin1 in Alzheimer Mouse Model (2) Analysis of Brain Post-Intranasal Administration of Insulin in Alzheimer and Induced Diabetic Mouse Models (3) Analysis Of Proteome Changes In The Parietal Lobule Of Rhesus Monkey Non-Human Primate Following Resveratrol Supplementation as a Part of a Western-Diet. [D] . Swomley, Aaron Michael. 2017

机译：氧化应激和蛋白质组学研究的神经退行性疾病的年龄相关代谢功能障碍的哺乳动物模型：（1）阿尔茨海默病小鼠模型中Pin1的上调（2）鼻内注射胰岛素对老年性痴呆症小鼠和诱导的糖尿病小鼠模型的分析（3）白藜芦醇补充作为西方饮食的一部分，恒河猴非人类灵长类动物顶叶小叶蛋白质组变化的分析。
6. Generation of Genetically Engineered Non-Human Primate Models of Brain Function and Neurological Disorders [O] . Jung Eun Park, Afonso C. Silva -1

机译：基因改造的非人类灵长类动物脑功能和神经系统疾病模型的生成
7. The Fine Arts, Neurology, and Neuroscience. Neuro-Historical Dimensions. Edited by Stanley Finger, Dahlia W. Zaidel, François Boller, Julien Bougousslavsky. Amsterdam; Oxford, Elsevier, 2013. 300 p. (Progress in Brain Research, vol. 203). I 206.–. ISBN 978-0-444-62730-8/The Fine Arts, Neurology, and Neuroscience. New Discoveries and Changing Landscapes. Edited by Stanley Finger, Dahlia W. Zaidel, François Boller, Julien Bogous - slavsky. Amsterdam; Oxford, Elsevier, 2013. 260 p. (Progress in Brain Research, vol. 204). I 206.–. ISBN 978-0-444-63287-6/Literature, Neurology, and Neuroscience. Historical and Literary Connections. Edited by Anne Stiles, Stanley Finger, Francois Boller. Amsterdam; Oxford, Elsevier, 2013. 368 p. (Progress in Brain Research, vol. 205). I 206.–. ISBN 978-0-444-63273-9/Literature, Neurology, and Neuroscience. Neurological and Psychiatric Disorders. Edited by Stanley Finger, François Boller, Anne Stiles. Amsterdam; Oxford, Elsevier, 2013. 252 p. (Progress in Brain Research, vol. 206). I 206.–. ISBN 978-0-444-63364-4 [O] . Fernando Vidal 2015

机译：美术，神经科和神经科学。神经历史尺寸。由斯坦利手指编辑，大丽花W. Zaidel，FrançoisBoller，Julien Bougousslavsky。阿姆斯特丹;牛津，elsevier，2013. 300 p。（大脑研究进展，第203卷）。我206.-。 ISBN 978-0-444-62730-8 /美术，神经学和神经科学。新发现和改变风景。由斯坦利手指编辑，大丽花W. Zaidel，FrançoisBoller，Julien Bogous - Slavsky。阿姆斯特丹;牛津，elsevier，2013. 260 p。（大脑研究进展，第204卷）。我206.-。 ISBN 978-0-444-63287-6 /文学，神经病学和神经科学。历史和文学联系。由Anne Stiles，Stanley Finger，Francois Boller编辑。阿姆斯特丹;牛津，elsevier，2013. 368 p。（大脑研究进展，第205卷）。我206.-。 ISBN 978-0-444-63273-9 /文献，神经学和神经科学。神经系统和精神病疾病。由斯坦利手指编辑，弗兰索斯·鲍克，安妮楼梯。阿姆斯特丹;牛津，elsevier，2013. 252 p。（大脑研究进展，第206卷）。我206.-。 ISBN 978-0-444-63364-4

Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates

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