Mapping of Protein-protein Interactions: Web-based Resources for Revealing Interactomes

Gemovic Branislava; Sumonja Neven; Davidovic Radoslav; Perovic Vladimir; Veljkovic Nevena

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Mapping of Protein-protein Interactions: Web-based Resources for Revealing Interactomes

机译：蛋白质 - 蛋白质相互作用的映射：基于网络的揭示犬的资源

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Background: The significant number of protein-protein interactions (PPIs) discovered by harnessinv, concomitant advances in the fields of sequencing, crystallography, spectrometry and two-hybrid screening suggests astonishinv, prospects for remodelling drug discovery. The PPI space which includes up to 650 000 entities is a remarkable reservoir of potential therapeutic targets for every human disease. In order to allow modern drug discovery programs to leverage this, we should be able to discern complete PPI maps associated with a specific disorder and corresponding normal physiology.

机译：背景技术：HarnessinV发现的大量蛋白质 - 蛋白质相互作用（PPI），伴随测序，结晶，光谱和双杂交筛查领域的伴随地位，表明AstonishinV，重塑药物发现的前景。包括高达650 000个实体的PPI空间是每个人类疾病的潜在治疗目标的显着储层。为了让现代药物发现程序利用这一点，我们应该能够辨别与特定疾病相关的完整PPI地图和相应的正常生理学。

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《Current medicinal chemistry》 |2019年第21期|共21页
作者
Gemovic Branislava; Sumonja Neven; Davidovic Radoslav; Perovic Vladimir; Veljkovic Nevena;
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作者单位

Univ Belgrade Ctr Multidisciplinary Res Inst Nucl Sci Vinca POB 522 Belgrade Serbia;

Univ Belgrade Ctr Multidisciplinary Res Inst Nucl Sci Vinca POB 522 Belgrade Serbia;

Univ Belgrade Ctr Multidisciplinary Res Inst Nucl Sci Vinca POB 522 Belgrade Serbia;

Univ Belgrade Ctr Multidisciplinary Res Inst Nucl Sci Vinca POB 522 Belgrade Serbia;

Univ Belgrade Ctr Multidisciplinary Res Inst Nucl Sci Vinca POB 522 Belgrade Serbia;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Protein-protein interactions; computational predictions; predictive performance; high-throughput experimental techniques; interactome datasets; databases;

机译：蛋白质 - 蛋白质相互作用;计算预测;预测性能;高通量实验技术;互乱数据集;数据库;

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1. Mapping of Protein-protein Interactions: Web-based Resources for Revealing Interactomes [J] . Gemovic Branislava, Sumonja Neven, Davidovic Radoslav, Current medicinal chemistry . 2019,第21期

机译：蛋白质 - 蛋白质相互作用的映射：基于网络的揭示犬的资源
2. Mapping Plant Interactomes Using Literature Curated and Predicted Protein-Protein Interaction Data Sets [J] . Lee KiYoung, Thorneycroft David, Achuthan Premanand, The Plant Cell . 2010,第4期

机译：使用文献管理和预测的蛋白质-蛋白质相互作用数据集定位植物相互作用
3. Structural domain-domain interactions: assessment and comparison with protein-protein interaction data to improve the interactome. [J] . Prieto C, De Las Rivas J Proteins: Structure, Function, and Genetics . 2010,第1期

机译：结构域-结构域相互作用：评估和与蛋白质-蛋白质相互作用数据进行比较以改善相互作用组。
4. Improving the Detection of Protein Complexes by Predicting Novel Missing Interactome Links in the Protein-Protein Interaction Network [C] . Nazar Zaki, Hany Alashwal Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：通过预测蛋白质-蛋白质相互作用网络中新型缺失的相互作用组链接来改善蛋白质复合物的检测
5. Small molecule modulation of protein-protein interactions: A. Microtubule-associated proteins affected by paclitaxel. B. Protein-protein interactions induced by bifunctional molecules. [D] . Barco, Joseph William. 2001

机译：蛋白质-蛋白质相互作用的小分子调节：A.受紫杉醇影响的微管相关蛋白质。 B.双功能分子诱导的蛋白质-蛋白质相互作用。
6. Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome [O] . Arun K Ramani, Razvan C Bunescu, Raymond J Mooney, 2005

机译：合并一组已知的人类蛋白质-蛋白质相互作用以准备大规模绘制人类相互作用组
7. Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome [O] . Ramani Arun K, Bunescu Razvan C, Mooney Raymond J, 2005

机译：合并一组已知的人类蛋白质-蛋白质相互作用，以准备大规模绘制人类相互作用组

Mapping of Protein-protein Interactions: Web-based Resources for Revealing Interactomes

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