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首页> 外文期刊>Current Molecular Biology Reports >Connecting Bone and Fat: the Potential Role for Sclerostin
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Connecting Bone and Fat: the Potential Role for Sclerostin

机译：连接骨骼和脂肪：硬化素的潜在作用

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Purpose of Review Sclerostin (SOST), a protein secreted from mature osteocytes in response to mechanical unloading and other stimuli, inhibits the osteogenic Wnt/|3-catenin pathway in mesenchymal stem cells (MSCs) impeding their ability to differentiate into mineralizing osteoblasts. This review summarizes the crosstalk between adipose tissue and the bone. It also reviews the origin, regulation, and role of SOST in oste-ogenesis and brings attention to an emerging role of this protein in the regulation of adipogenesis. Recent Findings Bone-derived molecules that drive MSC ad-ipogenesis have not previously been identified, but recent findings suggest that SOST signaling may induce adipogene-sis. In vivo SOST acts locally to induce changes in the boneand, in vitro, increases adipogenesis in 3T3-L1 preadipocytes. Summary SOST is able to induce adipogenesis in certain preadipocytes, however, bone-specific studies are needed to determine the effect of local SOST concentrations in healthy and disease models on bone marrow adipose tissue.
机译：审查燃气蛋白（SOST）的目的，响应于机械卸载和其他刺激的成熟骨细胞分泌的蛋白质，抑制间充质干细胞（MSCs）中的成骨WNT / | 3-连环蛋白途径，其妨碍它们分化为矿化成骨细胞的能力。本综述总结了脂肪组织与骨之间的串扰。它还审查了SOST在OSTE-IONECAESES中的起源，调节和作用，并提请注意这种蛋白质在脂肪发生调节中的新兴作用。最近发现骨衍生的分子以前没有识别出来的驱动MSC ad-iPogenesis，但最近的发现表明SOST信号传导可能诱导己二烯-SIS。在体内SOST局部作用于诱导苯二甲酸的变化，体外，增加3T3-L1前脂肪细胞的脂肪组织。发明内容能够在某些前脂肪细胞中诱导脂肪生成，然而，需要骨骼特异性研究来确定局部SOST浓度在骨髓脂肪组织中健康和疾病模型的影响。

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