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Novel analgesics in ambulatory surgical patients

机译：动态手术患者的新型镇痛药

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Purpose of review The increasing number of procedures done in the ambulatory surgical setting necessitates the need for analgesic modalities that enable the management of postsurgical pain with fast onset, predictable duration of action, and minimal need for management of undesirable side-effects. Recent findings The novel strategies for administration of local anesthetics in the ambulatory setting include prolonging their analgesic action at the site of surgical trauma while reducing systemic effects that result from their metabolism. Development of opioids aims to address receptor sites that provide for modulation of pain perception while reducing systemic, central effects of mu-receptor agonism. Other, more titratable agents with analgesic properties are also addressed. Local anesthetics, opioids, and NSAIDS are the mainstay of multimodal analgesic management, and as such, improving their efficacy in the ambulatory surgical setting remains the primary focus. However, as knowledge of the modulating pathways involved in transduction of pain increases, newer agents that utilize this knowledge are also becoming more widely available.
机译：审查越来越多的手术手术制定的程序越来越需要需要镇痛方式，使能源疼痛的管理能够快速发作，可预测的行动持续时间，并且对不良副作用的管理最小的需求。最近的发现，在动态环境中局部麻醉剂施用的新策略包括在手术创伤部位延长其镇痛作用，同时降低由其新陈代谢导致的全身效应。阿片类药物的发展旨在解决患有疼痛感知的受体遗址，同时降低穆受体激动主义的全身性效应。还解决了其他，具有镇痛性的其他可滴定剂。局部麻醉剂，阿片类药物和NSAID是多模式镇痛管理的主干，因此，改善他们在外科手术环境中的功效仍然是主要的重点。然而，随着对疼痛转导的调节途径的了解增加，利用这种知识的更新剂量也变得更加广泛。

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