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The Role of Platelet-Rich Plasma in Muscle Healing

机译:富血小板血浆在肌肉愈合中的作用

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摘要

The healing of a muscle injury is a complex and dynamic process characterized by different overlapping phases resulting in the restoration of the anatomic continuity and function. This process, triggered by the tissue injury itself, is modulated by different growth factors capable of directing the recruitment, duplication, activation, and differentiation of different cell types. This key role played by different growth factors is the basis of the use of platelet-rich plasma in several circumstances, all of them characterized by the need of activating or ameliorating the process of tissue repair. There is an extensive documentation of in vitro and in vivo studies demonstrating the safety and efficacy of growth factors in the muscle healing process. Unfortunately, for many different reasons, experimental results are usually difficult to interpret, clinical results are controversial, and the relevance of use is still debatable. The present article aims to review the available scientific literature with particular focus on actual clinical applications.
机译:肌肉损伤的愈合是一种复杂的和动态过程,其特征在于不同的重叠阶段,导致恢复解剖连续性和功能。由组织损伤本身引发的该过程由能够引导不同细胞类型的招生,重复,激活和分化的不同生长因子调节。不同增长因素发挥的这种关键作用是在几种情况下使用富含血小板的血浆的基础,所有这些都是需要激活或改善组织修复过程的需要。体外和体内研究有一个广泛的文献,证明了肌肉愈合过程中生长因子的安全性和有效性。不幸的是,出于许多不同的原因,实验结果通常难以解释,临床结果是有争议的,并且使用的相关性仍然是争议的。本文旨在审查可用的科学文献,特别关注实际的临床应用。

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  • 来源
    《Current sports medicine reports.》 |2017年第6期|共5页
  • 作者单位

    Univ Rome Foro Italico Dept Movement Human &

    Hlth Sci Piazza Lauro de Bosis 15 I-00194 Rome;

    Univ Rome Foro Italico Dept Movement Human &

    Hlth Sci Piazza Lauro de Bosis 15 I-00194 Rome;

    Univ Rome Foro Italico Dept Movement Human &

    Hlth Sci Piazza Lauro de Bosis 15 I-00194 Rome;

    Parthenope Univ Naples Dept Movement &

    Wellness Sci Naples Italy;

    Univ Rome Foro Italico Dept Movement Human &

    Hlth Sci Piazza Lauro de Bosis 15 I-00194 Rome;

    Univ Rome Foro Italico Dept Movement Human &

    Hlth Sci Piazza Lauro de Bosis 15 I-00194 Rome;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种医学;
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