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首页> 外文期刊>Current opinion in gastroenterology >Pediatric inflammatory bowel diseases: coming of age.
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Pediatric inflammatory bowel diseases: coming of age.

机译：小儿炎症肠疾病：年龄的到来。

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PURPOSE OF REVIEW: Inflammatory bowel diseases (IBD) comprise a heterogeneous group of distinct intestinal disorders. Here, we discuss the concept of childhood-onset IBD as separate disease forms within a larger multifactorial disease category. RECENT FINDINGS: There are excellent epidemiological data indicating that the incidence of pediatric IBD, mainly Crohn's disease, is still increasing over the last decades, with indicators of more extensive and more severe disease presentations in children compared to adults, also reflected by higher levels of humoral immune responses. Recent genetic scans allowed to identify particular susceptibility genes for pediatric IBD forms, such as IL27 or probably DcR3. Early postnatal onset forms of IBD might reflect monogenetic causes, as suggested with the finding of IL10 signaling defects that may define a new form of IBD. SUMMARY: There are good epidemiological, genetic and clinical data to distinguish different forms of IBD, particularly forms starting early in life. Profound insights in the molecular basis of immune dysregulation in IBD have been gained over the last few years. These recent discoveries will nourish and substantially stimulate the future search for precise cause(s) responsible for life-long intestinal inflammation and it will help to explain the still ongoing rise in incidence in childhood IBD.
机译：审查目的：炎症性肠病（IBD）包含异质的不同肠道病症。在这里，我们讨论童年发病IBD的概念，作为单独的疾病形式在更大的多重疾病类别中。最近的发现：有优异的流行病学数据，表明儿科IBD的发生率，主要是克罗恩病，在过去几年中仍在增加，与成年人相比，儿童更广泛和更严重的疾病介绍的指标，也反映了更高水平的体液免疫反应。最近遗传扫描允许识别儿科IBD形式的特定易感基因，例如IL27或可能DCR3。 IBD的早期产后发病形式可能反映单一的原因，如同查找可以定义一种新形式的IBD的IL10信号缺陷。摘要：有很好的流行病学，遗传和临床数据，以区分不同形式的IBD，特别是在生命早期开始的形式。在过去几年中，IBD中IBD免疫失调的分子基础的深刻洞察力已经获得。这些最近的发现将滋养并大大刺激未来寻求对终原肠炎症负责的确切原因，并有助于解释童年IBD的发病率仍然持续升高。

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