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首页> 外文期刊>Current opinion in gastroenterology >Proton pump inhibitors and risk of Clostridium difficile infection: association or causation?
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Proton pump inhibitors and risk of Clostridium difficile infection: association or causation?

机译：质子泵抑制剂和梭菌差异感染风险：联想或因果关系？

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Purpose of reviewThe rising burden of Clostridium difficile infection (CDI) requires urgent identification of preventable risk factors. Observational studies suggest an association between proton-pump inhibitor (PPI) use and CDI risk.Recent findingsKey historical literature on PPI and CDI associations is reviewed as a prelude to evaluating the plausibility of a causative association. Impactful literature from the past 18 months is examined in detail and critically appraised through the lens of the Bradford Hill Criteria for determination of causality. The PPI and CDI association has been studied extensively and is valid. Nonetheless, causality is not proven due to extensive and difficult to control confounding in observational studies of CDI patient populations with complex comorbidities.SummaryIn the authors' opinion, systematic discontinuation of PPIs in patients at risk for CDI is not warranted based on current evidence. Well controlled prospective human studies are needed. Careful and repeated consideration should be given to all PPI prescriptions to avoid potential adverse effects.
机译：审查梭菌性艰难梭菌感染的上升（CDI）的目的需要紧急鉴定可预防的危险因素。观察性研究表明质子泵抑制剂（PPI）使用和CDI风险之间的关联。审查了PPI和CDI协会的调查面前历史文学作为评估致病性协会合理性的前奏。从过去18个月的影响力文学进行了详细检查，并通过布拉德福德山山标准的镜头来确定因果关系。 PPI和CDI关联已被广泛研究并有效。尽管如此，由于广泛且难以控制CDI患者人群与复杂的合并性的观察研究的混淆，因此不会被证明。ummaryin在作者的意见中，基于当前证据不需要对CDI风险的患者进行PPI的系统性停药。需要良好控制的前瞻性人类研究。应仔细和重复考虑所有PPI处方，以避免潜在的不利影响。

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