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首页> 外文期刊>Current opinion in hematology >The flux of iron through ferritin in erythrocyte development
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The flux of iron through ferritin in erythrocyte development

机译：通过铁蛋白在红细胞发育中的铁通态

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Purpose of review Terminal differentiation of erythropoietic progenitors requires the rapid accumulation of large amounts of iron, which is transported to the mitochondria, where it is incorporated into heme. Ferritin is the sole site of iron storage present in the cytosol. Yet the role of iron accumulation into ferritin in the context of red cell development had not been clearly defined. Early studies indicated that at the onset of terminal differentiation, iron initially accumulates in ferritin and precedes heme synthesis. Whether this accumulation is physiologically important for red cell development was unclear until recent studies defined an obligatory pathway of iron flux through ferritin. Recent findings The iron chaperone functions of poly rC-binding protein 1 (PCBP1) and the autophagic cargo receptor for ferritin, nuclear co-activator 4 (NCOA4) are required for the flux of iron through ferritin in developing red cells. In the absence of these functions, iron delivery to mitochondria for heme synthesis is impaired. Summary The regulated trafficking of iron through ferritin is important for maintaining a consistent flow of iron to mitochondria without releasing potentially damaging redox-active species in the cell. Other components of the iron trafficking machinery are likely to be important in red cell development.
机译：审查促红细胞祖的末端分化需要大量铁的快速积累，其被运输到线粒体，其中掺入血红素中。铁蛋白是胞质溶胶中存在的铁储存的唯一部位。然而，在红细胞开发背景下，铁积聚到铁蛋白的作用尚未明确定义。早期研究表明，在末端分化的开始，铁最初在铁蛋白中积累并在血红素合成中累积。在最近的研究确定通过铁蛋白的铁通量的强制性途径定义了这种积累是否存在生理学上不清楚。最近发现聚RC结合蛋白1（PCBP1）的铁伴伴官能团和铁素的自噬型货物受体，核心辅助剂4（NCOA4）需要铁通过铁素在发育红细胞中的铁蛋白。在没有这些功能的情况下，损害了对血红素合成的线粒体的铁输送。发明内容通过铁蛋白的规定的铁贩运铁对于维持线粒体的一致铁流是重要的，而不会在细胞中释放可能损害潜在的氧化还原活性物质。铁贩运机械的其他组成部分在红细胞发展中可能是重要的。

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