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首页> 外文期刊>Current Forestry Reports >Sustained Delivery of BMP-2-Related Peptide from the True Bone Ceramics/Hollow Mesoporous Silica Nanoparticles Scaffold for Bone Tissue Regeneration
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Sustained Delivery of BMP-2-Related Peptide from the True Bone Ceramics/Hollow Mesoporous Silica Nanoparticles Scaffold for Bone Tissue Regeneration

机译：从真正的骨陶瓷/中空介孔二氧化硅纳米粒子支架上持续递送BMP-2相关肽，用于骨组织再生

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摘要

Bone morphogenetic protein 2 (BMP-2) is one of the most important factors for bone tissue formation. A number of BMP-2 related small molecule bioactive peptides have been designed and shown to be equally effective in osteogenic activity. In this report, we P28) and designed a delivery system to regulate the controlled release of P28 from true bone ceramics (TBC) combined with an enlarged pore hollow P28 from the TBC/HMSN scaffold was slower than that from the TBC scaffold. An in vitro cell experiment of the TBC/HMSN/P28 scaffold was tested with MC3T3-E1 cells in comparison to TBC, TBC/HMSN, and TBC/P28 scaffolds. Our results demonstrated that the TBC/HMSN/P28 scaffold had better effects on promoting proliferation and osteogenic differentiation of MC3T3-E1 cells than TBC, TBC/HMSN, and TBC/P28 scaffolds. After four kinds of scaffolds were implanted into a rabbit radius critical bone defect for 6 and 12 weeks, the radiographic and histological examination indicated that this osteogenic delivery system TBC/HMSN/P28 scaffold effectively induced bone regeneration in vivo. Therefore, the TBC/HMSN/P28 scaffold can promote proliferation and osteogenic differentiation of MC3T3-E1 cells in vitro and new bone tissue generation in vivo. This study provides a promising scaffold for bone tissue engineering and regenerative medicine.
机译：骨形态发生蛋白2（BMP-2）是骨组织形成最重要的因素之一。已经设计了许多BMP-2相关的小分子生物活性肽，并且显示在成骨活性方面同样有效。在本报告中，我们P28）并设计了一种传递系统来调节来自真骨陶瓷（TBC）的P28的控制释放与来自TBC / HMSN支架的扩大孔隙空心P28比来自TBC支架的放大慢。与TBC，TBC / HMSN和TBC / P28支架相比，用MC3T3-E1细胞测试TBC / HMSN / P28支架的体外细胞实验。我们的研究结果表明，TBC / HMSN / P28支架对促进MC3T3-E1细胞的增殖和骨质发生分化具有比TBC，TBC / HMSN和TBC / P28支架的效果更好。在将四种支架中植入兔半径临界骨缺陷6和12周后，射线照相和组织学检查表明，这种成骨输送系统TBC / HMSN / P28支架有效地诱导体内骨再生。因此，TBC / HMSN / P28支架可以促进体内体外和新骨组织产生的MC3T3-E1细胞的增殖和骨质发生分化。本研究为骨组织工程和再生医学提供了有前途的支架。

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  • 来源
    《Current Forestry Reports》 |2018年第1期|共11页
  • 作者

    Cui Wei; Liu Qianqian; Yang Liang; Wane Ke; Sun Tingfang; Ji Yanhui; Liu Liping; Yu Wei; Qu Yanzhen; Wang Junwen; Zhao Zhigang; Zhu Jintao; Guo Xiaodong;

  • 作者单位

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

    HUST Sch Chem &

    Chem Engn Minist Educ Key Lab Mat Chem Energy Convers &

    Storage Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

    HUST Sch Chem &

    Chem Engn Minist Educ Key Lab Mat Chem Energy Convers &

    Storage Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

    HUST Sch Chem &

    Chem Engn Minist Educ Key Lab Mat Chem Energy Convers &

    Storage Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

    HUST Tongji Med Coll Wuhan Puai Hosp Dept Orthopaed Wuhan 430032 Hubei Peoples R China;

    HUST Tongji Med Coll Wuhan Puai Hosp Dept Orthopaed Wuhan 430032 Hubei Peoples R China;

    HUST Sch Chem &

    Chem Engn Minist Educ Key Lab Mat Chem Energy Convers &

    Storage Wuhan 430074 Hubei Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Union Hosp Dept Orthopaed Wuhan 430022 Hubei Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 林业;
  • 关键词

    BMP-2; synthetic peptide; hollow mesoporous silica nanoparticles; true bone ceramics; osteogenic differentiation; bone tissue regeneration;

    机译：BMP-2;合成肽;中空介孔二氧化硅纳米粒子;真骨陶瓷;成骨分化;骨组织再生;

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