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Monocytes and macrophages in atherogenesis

机译:单核细胞和巨噬细胞在体育血肿中

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Purpose of review Monocytes and macrophages are key players in the pathogenesis of atherosclerosis and dictate atherogenesis growth and stability. The heterogeneous nature of myeloid cells concerning their metabolic and phenotypic function is increasingly appreciated. This review summarizes the recent monocyte and macrophage literature and highlights how differing subsets contribute to atherogenesis. Recent findings Monocytes are short-lived cells generated in the bone marrow and released to circulation where they can produce inflammatory cytokines and, importantly, differentiate into long-lived macrophages. In the context of cardiovascular disease, a myriad of subtypes, exist with each differentially contributing to plaque development. Herein we describe recent novel characterizations of monocyte and macrophage subtypes and summarize the recent literature on mediators of myelopoiesis.
机译:审查单核细胞和巨噬细胞的目的是动脉粥样硬化发病机制的关键球员,并决定血液发生生长和稳定性。 毫髓细胞的异质性质越来越高兴地欣赏其代谢和表型功能。 本综述总结了最近的单核细胞和巨噬细胞文献,并突出了不同的子集对αsthergesis有贡献。 最近的发现单核细胞是骨髓中产生的短暂细胞,并释放到它们可以产生炎症细胞因子的循环,重要的是,分化为长期巨噬细胞。 在心血管疾病的背景下,每种亚型亚型,每个差异有助于斑块发育。 在此,我们描述了最近单核细胞和巨噬细胞亚型的新型特征,并总结了近期髓鞘介质的文献。

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