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Investigation of RNA-RNA InteractionsUsing the RISE Database

机译：RNA-RNA对崛起数据库的关系调查

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摘要

RNA-RNA interactions (RRIs) are essential to understanding the regulatorymechanisms of RNAs. Mapping RRIs in vivo in a transcriptome-wide mannerremained challenging until the recent development of several sequencing-basedtechnologies. However, RRIs generated from large-scale studies had not beensystematically collected and analyzed before. This article introduces RISE, adatabase of the RNA Interactome from Sequencing Experiments. RISE providesa comprehensive collection of RRIs in human, mouse, and yeast, derivedfrom transcriptome-wide sequencing experiments, as well as targeted sequencingstudies and other public databases/datasets. To facilitate better understandingof the biological roles of these RRIs, RISE also offers rich functionalannotations involving RNAs, and an interactive interface to explore the analysisresults. Here, we provide a brief description of the RISE website and astep-by-step protocol for using RISE to study RRIs.
机译：RNA-RNA相互作用（RRI）对于了解RNA的监管机制至关重要。 在体内测绘rris以转录组型典型的挑战，直到最近的几个序列的基于序列的技术。 然而，从大规模研究产生的rris并未在系统上收集和分析。 本文介绍了RNA互蛋白从测序实验的升高的升高。 升高为人，小鼠和酵母中的RRI综合收集，源自转录组宽的测序实验，以及目标序列序列和其他公共数据库/数据集。 为了便于更好地理解这些RRI的生物学作用，因此还提供涉及RNA的丰富的功能annotations，以及探索分析事务的互动界面。 在这里，我们提供了对使用崛起来研究RRI的崛起网站和逐步协议的简要说明。

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  • 作者

    Yanyan Ju; Jing Gong; Yucheng T. Yang; Qiangfeng Cliff Zhang;

  • 作者单位

    MOE Key Laboratory of Bioinformatics Beijing Advanced Innovation Center forStructural Biology Center for Synthetic and Systems Biology Tsinghua-Peking JointCenter for Life Sciences School of Life Sciences Tsinghua University Beijing China;

    MOE Key Laboratory of Bioinformatics Beijing Advanced Innovation Center forStructural Biology Center for Synthetic and Systems Biology Tsinghua-Peking JointCenter for Life Sciences School of Life Sciences Tsinghua University Beijing China;

    Department of Molecular Biophysics and Biochemistry Yale University New Haven Connecticut;

    MOE Key Laboratory of Bioinformatics Beijing Advanced Innovation Center forStructural Biology Center for Synthetic and Systems Biology Tsinghua-Peking JointCenter for Life Sciences School of Life Sciences Tsinghua University Beijing China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    interaction; RISE; RNA; RNA-RNA; RNA structure; sequencingexperiments;

    机译：相互作用;上升;RNA;RNA RNA;RNA结构;测序分析;

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