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首页> 外文期刊>Current Protocols in Bioinformatics >Analysis and Visualization of DynamicNetworks Using the DyNet App forCytoscape
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Analysis and Visualization of DynamicNetworks Using the DyNet App forCytoscape

机译：使用Dynet App forcytoscape的DyneNetWorks的分析与可视化

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摘要

Biological processes are regulated at a cellular level by tightly controlled molecularinteraction networks, which are collectively known as the interactome.The interactome is not a static entity, but instead is dynamically reorganizedor “rewired” under varying temporal, spatial, and environmental conditions.Most network analysis and visualization tools have, to date, been developed forstatic representations of molecular interaction data. Here, we describe a protocolthat provides a step-by-step guide to DyNet, a Cytoscape 3 applicationthat facilitates the visualization and analysis of dynamic molecular interactionnetworks. DyNet represents a dynamic network as a set of state graphs that aresynchronized in their layout. This synchronization is managed in real time andis automatically updated when a graph is manipulated by a user (e.g., dragging,zooming, moving a node). DyNet also provides several statistical toolsenabling users to quickly identify and analyze the most ‘rewired’ nodes acrossmany network states.
机译：通过紧密控制的分子互动网络在细胞水平下对生物过程调节，其被统称为互乱组。互联蛋白组不是静态实体，而是在不同的时间，空间和环境条件下动态重新组织“重新束”。最多的网络迄今为止，分析和可视化工具已经开发了分子交互数据的静态表示。这里，我们描述了一个Protectthat提供了一个逐步的Dynet指南，Cytoskape 3 Applicationsthat促进了动态分子互动的可视化和分析。 Dynet表示动态网络，作为一组状态图，其在其布局中同步。当用户操纵图形时DYNET还提供了几种统计工具，以便快速识别和分析跨越网络状态的最大“重新运行”节点。

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  • 作者

    John Salamon; Ivan H. Goenawan; David J. Lynn;

  • 作者单位

    EMBL Australia Group Infection and Immunity Theme South Australian Medical andHealth Research Institute North Terrace Adelaide South Australia Australia;

    EMBL Australia Group Infection and Immunity Theme South Australian Medical andHealth Research Institute North Terrace Adelaide South Australia Australia;

    EMBL Australia Group Infection and Immunity Theme South Australian Medical andHealth Research Institute North Terrace Adelaide South Australia Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    Cytoscape 3; dynamic network; DyNet; network analysis;

    机译：Cytoscape 3;动态网络;DYNET;网络分析;

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