Anticancer Hybrid Combinations: Mechanisms of Action, Implications and Future Perspectives

Dominguez-Martin Eva M.; Diaz-Lanza Ana M.; Faustino Celia M. C.

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Anticancer Hybrid Combinations: Mechanisms of Action, Implications and Future Perspectives

机译：抗癌混合组合：行动机制，影响和未来的观点

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The exponential growth of cancer cases worldwide together with recent advances concerning the pathophysiological mechanisms of the disease at the molecular level led to a paradigm shift in chemotherapy, from monotherapy to targeted drug combination regimens. However, adverse effects and the emergence of multidrug resistance (MDR) limit the effectiveness of these therapies. In this context, hybrid combinations mixing anticancer drugs and bioactive phytochemical components from medicinal plants, or even plant extracts, that can act synergistically on multiple targets and signaling pathways represent a promising approach with the potential to expand the current therapeutic arsenal.

机译：全世界癌症病例的指数增长与近期疾病的分子水平病理生理机制的进展导致了化疗的范式转变，从单药治疗到靶向药物组合方案。然而，不利影响和多药耐药的出现（MDR）限制了这些疗法的有效性。在这种情况下，将抗癌药物和生物活性植物化学成分与药用植物或甚至植物提取物混合的杂种组合，这些组分可以在多个靶标和信号传导途径上协同作用代表有希望扩大当前治疗库的有希望的方法。

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来源
《Current pharmaceutical design》 |2018年第36期|共22页
作者
Dominguez-Martin Eva M.; Diaz-Lanza Ana M.; Faustino Celia M. C.;
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作者单位

Univ Alcala De Henares Fac Pharm Dept Biomed Sci POB Carretera Madrid Barcelona Km 33-100;

Univ Alcala De Henares Fac Pharm Dept Biomed Sci POB Carretera Madrid Barcelona Km 33-100;

Univ Lisbon Fac Pharm iMed ULisboa Res Inst Med Ave Prof Gama Pinto P-1649003 Lisbon Portugal;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Hybrid combinations; combination therapy; synergy; cancer; multicomponent; multi-target; phytotherapy; integrative oncology;

机译：混合组合;联合治疗;协同作用;癌症;多组分;多目标;植物疗法;综合肿瘤学;

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1. Anticancer Hybrid Combinations: Mechanisms of Action, Implications and Future Perspectives [J] . Dominguez-Martin Eva M., Diaz-Lanza Ana M., Faustino Celia M. C. Current pharmaceutical design . 2018,第36期

机译：抗癌混合组合：行动机制，影响和未来的观点
2. Anticancer Actions of Omega-3 Fatty Acids – Current State and Future Perspectives [J] . Martina Wendel Axel R. Heller Anti-Cancer Agents in Medicinal Chemistry . 2009,第4期

机译：Omega-3脂肪酸的抗癌作用-现状和未来展望
3. Melatonin as a Chronobiotic / Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy [J] . David E. Blask Leonard A. Sauer Robert T. Dauchy Current Topics in Medicinal Chemistry . 2002,第2期

机译：褪黑素作为一种慢性生物/抗癌剂：细胞，生化和分子的作用机制及其对基于昼夜节律的癌症治疗的意义。
4. The Mechanism of the Apoptotic Effects in the Combination TherapyOf Anticancer Agents with Thalidomide [C] . Sun-Ju Choi, On-Hee Kim, Young-Don Hong, Annual meeting exposition of the Controlled Release Society . 2005

机译：抗癌药与沙利度胺联合治疗中凋亡作用的机制
5. Development of anticancer agents with novel mechanisms of action [D] . Chen, Wei 2010

机译：具有新作用机制的抗癌药的开发
6. Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives [O] . Robert Jenke, Nina Reßing, Finn K. Hansen, 2021

机译：HDAC抑制剂的抗癌治疗：基于机制的组合策略和未来的观点
7. Metal Anticancer Complexes - Activity, Mechanism of Action, Future Perspectives [O] . Alessio, Enzo, Guo, Zijian 2017

机译：金属抗癌复合物-活性，作用机理，未来展望
8. Hospital of the Future. Megatrends, Driving Forces, Barriers to Implementation, Overarching Perspectives, Major Trends into the Future, Implications for TATRC And Specific Recommendations for Action [R] . Schimpff, S. C. 2008

机译：未来医院。大趋势，驱动力，实施障碍，总体前景，未来主要趋势，对TaTRC的影响以及行动的具体建议

Anticancer Hybrid Combinations: Mechanisms of Action, Implications and Future Perspectives

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