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首页> 外文期刊>Bioelectrochemistry >A theranostic system based on nanocomposites of manganese oxide nanoparticles and a pH sensitive polymer: Preparation, and physicochemical characterization
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A theranostic system based on nanocomposites of manganese oxide nanoparticles and a pH sensitive polymer: Preparation, and physicochemical characterization

机译：一种基于氧化锰纳米粒子纳米复合材料的治疗系统及pH敏感聚合物：制备和物理化学表征

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摘要

A multifunctional nanocomposite theranostic system is constructed of manganese oxide (Mn3O4) nanoparticles (NPs), as a tumor diagnostic agent, in conjunction with polyacrylic acid (PM), as a pH-sensitive drug delivery agent, and methotrexate (MTX), as a model of targeting agent and anticancer drug, Physicochemical characteristics of the Mn3O4@PAA/MTX system is studied in detail by several techniques, including X-ray and Auger photoelectron spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, and electrochemical methods. The system performance is studied based on (i) in-vitro MRI measurements to support efficiency of the Mn3O4@PAA NPs as a diagnostic agent, (ii) drug release performance of the Mn3O4@PAA/MTX NPs at pHs of 5.4 and 7.4 through in-vitro method to evaluate application of the NPs as pH-sensitive nanocarriers for MTX, and (iii) impedance spectroscopy measurements to show Mn3O4@PAA/MTX NPs affinity for capturing of cancer cells. The results show that (i) Mn3O4@PAA NPs can be used as a contrast agent in MRI measurements (r(1 congruent to )6.5 mM(-1)s(-1)), (ii) the MTX, loaded on Mn3O4@PAA NPs, is released faster and more efficient at pH 5.4 than 7.4, and (iii) the GC-Mn3O4@PAA/MTX electrode system captures the 4T1 cells 3.32 times larger than L929 cells. (C) 2019 Published by Elsevier B.V.
机译：多官能纳米复合体静体系由氧化锰（MN3O4）纳米颗粒（NPS）构成，作为肿瘤诊断剂，与聚丙烯酸（PM）相结合，作为pH敏感的药物递送剂和甲氨蝶呤（MTX），为a靶向剂和抗癌药物的模型，通过多种技术详细研究了MN3O4 @ PAA / MTX系统的物理化学特性，包括X射线和螺旋钻光电子能，傅里叶变换红外光谱，X射线衍射，现场 - 发射扫描电子显微镜，透射电子显微镜和电化学方法。基于（i）体外MRI测量研究了系统性能，以支持MN3O4 @ Paa NPS作为诊断剂的效率，（ii）在5.4和7.4的pHS下的Mn3O4 @ Paa / MTX NP的药物释放性能在体外方法中评估NPS作为MTX的pH敏感纳米载体的应用，（III）阻抗光谱测量以显示用于捕获癌细胞的MN3O4 @ PAA / MTX NPS亲和力。结果表明，（i）MN3O4 @ PAA NPS可以用作MRI测量中的造影剂（R（1一致为）6.5 mm（-1）S（-1）），（ii）MTX，在MN3O4上加载@PAA NPS，在pH 5.4的pH 5.4时释放得更快，更高效，（iii）GC-MN3O4 @ PAA / MTX电极系统捕获4T1电池的3.32倍大于L929细胞。 （c）2019年由elestvier b.v发布。

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