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首页> 外文期刊>Abdominal radiology. >Can MR elastography be used to measure liver stiffness in patients with iron overload?
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Can MR elastography be used to measure liver stiffness in patients with iron overload?

机译：Elastapraphy可以用于测量铁过载患者的肝硬化吗？

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摘要

Untreated hepatic iron overload causes hepatic fibrosis and cirrhosis and can predispose to hepatocellular carcinoma. MR elastography (MRE) provides a non-invasive means to measure liver stiffness, which correlates with liver fibrosis but standard gradient recalled echo (GRE)-based MRE techniques fail in patients with high iron due to very low hepatic signal. Short echo time (TE) 2D spin echo echoplanar imaging (SE-EPI)-based MRE may allow measurement of stiffness in the iron loaded liver. The purpose of this study was to describe the use of such an MRE sequence in patients undergoing liver iron quantification by MRI. In our preliminary study of 43 patients with mean LIC of 9.3 mg/g (range 1.8-21.5 mg/ g), liver stiffness measurements could be made in 77% (33/43) of patients with a short TE, SE-EPI based MRE sequence. On average, mean LIC in patients with failed MRE was higher than in those with successful MRE (15.9 mg/g dry weight vs. 7.3 mg/g), but a cut-off value for successful MRE could not be established. Seven patients (21% of those with successful MRE) had liver stiffness values suggestive of the presence of significant fibrosis (> 2.49 kPa). A short TE, SE-EPI based MR elastography sequence allows successful measurement of liver stiffness in a majority of patients with liver iron loading, potentially allowing non-invasive screening for fibrosis.
机译：未经处理的肝脏铁过载导致肝纤维化和肝硬化，可以易于肝细胞癌。 Elastography（MRE）先生提供了一种非侵入性手段来测量肝硬化，与肝纤维化相关，但标准梯度召回的回声（GRE）基础的MRE技术因肝脏信号引起的高铁患者失败。短回声时间（TE）2D旋转回波旋转成像（SE-EPI），基础的MRE可以允许在铁装载肝脏中测量刚度。本研究的目的是描述在经过MRI接受肝脏铁定量的患者中使用这种MRE序列。在我们初步研究43例平均LIC患者9.3 mg / g（范围1.8-21.5mg / g），肝脏僵硬测量可以在77％（33/43）的患者中，基于SE-EPI的短TE mre序列。平均而言，MRE患者的平均LIC高于成功的MRE（15.9mg / g干重与7.3mg / g）的患者，但无法建立成功的MRE的截止值。七名患者（21％的人成功）具有肝脏僵硬值，提示存在显着纤维化（> 2.49kPa）。基于SE-EPI的ELASTOGRAGE序列允许成功测量肝脏铁载荷大多数患者的肝硬化，可能允许无侵入性筛选纤维化。

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