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首页> 外文期刊>Abdominal radiology. >Consistency of hepatocellular gadoxetic acid uptake in serial MRI examinations for evaluation of liver function
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Consistency of hepatocellular gadoxetic acid uptake in serial MRI examinations for evaluation of liver function

机译：肝细胞型丙酰基酸摄取在肝功能评价中的肝细胞型乙醛酸摄取的一致性

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Purpose To assess the consistency of liver enhancement in gadoxetic acid-enhanced magnetic resonance imaging (MRI) over serial examinations. Methods This retrospective study included 554 patients who underwent at least 2 serial gadoxetic acid-enhanced MRI scans at either 1.5 or 3.0 Tesla at our institution between 2014 and 2018. Signal intensities (SI) were measured on T1-weighted images before and approx. 20 min after intravenous injection of gadoxetic acid. Relative enhancement (RE) of the liver, liver-to-spleen SI ratio (LSR), and liver-to-muscle SI ratio (LMR) were calculated. Means were compared with the paired t test, Greenhouse-Geisser test, and linear mixed model analysis, accordingly. Multiple linear regression analysis was used to elucidate possible predictors of RE and bivariate correlation analysis of patient age with RE was performed. Results No statistically significant difference in RE, LSR, and LMR between two consecutive MRI scans was found when tested with paired t test or Greenhouse-Geisser test (n = 554, 519, and 554, respectively), while the latter revealed a statistically significant difference between the first and fourth MRI scan which was not confirmed in the linear mixed model. Patient age correlated negatively with RE of the liver 0 = 0.002), LSR O<0.001), and LMR 0 = 0.006). Conclusions Relative enhancement of the liver in the hepatobiliary phase of gadoxetic acid-enhanced MRI is consistent over successive examinations, different scanner types, and field strengths while correlating negatively with age, which further underscores the validity of gadoxetic acid-enhanced MRI as an imaging-based liver function test.
机译：目的评估肝增强酶增强型钆型磁共振成像（MRI）的一致性。方法该回顾性研究包括在2014年和2018年间在我们的机构的1.5或3.0特斯拉在我们的机构中​​完成了554名患者，在2014年和2018年之间进行了1.5或3.0特斯拉。信号强度（Si）在T1加权图像上测量以前和约。静脉注射钆酸后20分钟。计算肝脏的相对增强（RE），肝转液Si比（LSR）和肝脏肌肉Si比（LMR）。相应地将手段与配对T试验，温室 - 阁测试和线性混合模型分析进行比较。使用多种线性回归分析来阐明患者年龄的Re和Bifariate相关分析的可能预测因子进行RE。结果在双连续的MRI扫描之间没有统计学上没有统计学意义差异，当使用配对的T试验或温室 - 揭示测试（分别为554,519和554）时发现了两个连续的MRI扫描之间的差异，而后者揭示了统计学意义在线性混合模型中未确认的第一和第四MRI扫描之间的差异。患者年龄与肝脏Re 0 = 0.002的RE负相关，LSR O <0.001），LMR 0 = 0.006）。结论偶氮酸增强MRI肝胆碱相对增强肝胆碱相对于连续的考试，不同的扫描仪类型和场强，同时与年龄负相关，这进一步强调了乙酰乙酸增强MRI作为成像的有效性 - 基于肝功能测试。

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