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High-resolution diffusion-weighted imaging for monitoring breast cancer treatment response

机译:用于监测乳腺癌治疗反应的高分辨率扩散加权成像

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摘要

Rationale and Objectives: The aim of this work was to compare a high-resolution diffusion-weighted imaging (HR-DWI) acquisition (voxel size = 4.8 mm3) to a standard diffusion-weighted imaging (STD-DWI) acquisition (voxel size = 29.3 mm3) for monitoring neoadjuvant therapy-induced changes in breast tumors. Materials and Methods: Nine women with locally advanced breast cancer were imaged with both HR-DWI and STD-DWI before and after 3 weeks (early treatment) of neoadjuvant taxane-based treatment. Tumor apparent diffusion coefficient (ADC) metrics (mean and histogram percentiles) from both DWI methods were calculated, and their relationship to tumor volume change after 12 weeks of treatment (posttreatment) measured by dynamic contrast enhanced magnetic resonance imaging was evaluated with a Spearman's rank correlation. Results: The HR-DWI pretreatment 15th percentile tumor ADC (P = .03) and early treatment 15th, 25th, and 50th percentile tumor ADCs (P = .008, .010, .04, respectively) were significantly lower than the corresponding STD-DWI percentile ADCs. The mean tumor HR-ADC was significantly lower than STD-ADC at the early treatment time point (P = .02), but not at the pretreatment time point (P = .07). A significant early treatment increase in tumor ADC was found with both methods (P .05). Correlations between HR-DWI tumor ADC and posttreatment tumor volume change were higher than the STD-DWI correlations at both time points and the lower percentile ADCs had the strongest correlations. Conclusion: These initial results suggest that the HR-DWI technique has potential for improving characterization of low tumor ADC values over STD-DWI and that HR-DWI may be of value in evaluating tumor change with treatment. ? 2013 AUR.
机译:理由和目标:这项工作的目的是将高分辨率扩散加权成像(HR-DWI)采集(体素尺寸= 4.8mm3)与标准扩散加权成像(STD-DWI)采集进行比较(Voxel Size = 29.3 mm3)用于监测Neoadjuvant治疗诱导的乳腺肿瘤变化。材料和方法:在Neoadjuvant紫杉烷的治疗前后,HR-DWI和STD-DWI患有局部晚期乳腺癌的九个妇女。计算来自DWI方法的肿瘤表观扩散系数(ADC)度量(均值和直方图百分比),并通过动态对比增强磁共振成像测量12周的治疗(后处理)后与肿瘤体积变化的关系进行评估,并用Spearman的等级评估相关性。结果:HR-DWI预处理15百分位肿瘤ADC(P = .03)和早期治疗15th,第25号和第50百分位肿瘤ADC(P = .008,.010,.04,分别)显着低于相应的STD -dwi百分位数ADC。平均肿瘤HR-ADC在早期治疗时间点(P = .02)处显着低于STD-ADC,但不在预处理时间点(P = .07)。用两种方法发现肿瘤ADC的显着早期治疗(P <.05)。 HR-DWI肿瘤ADC和后处理肿瘤体积变化的相关性高于两个时间点的STD-DWI相关性,较低百分位的ADC具有最强的相关性。结论:这些初始结果表明,HR-DWI技术具有改善STD-DWI的低肿瘤ADC值表征的可能性,并且HR-DWI可能具有评估肿瘤变化与治疗的价值。还2013年AUR。

著录项

  • 来源
    《Academic radiology》 |2013年第5期|共9页
  • 作者单位

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Bioengineering University of California Berkeley CA United States;

    Department of Epidemiology and Biostatistics University of California Box 1667 San Francisco;

    Applied Science Laboratory GE Healthcare Menlo Park CA United States;

    Applied Science Laboratory GE Healthcare Menlo Park CA United States;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

    Department of Radiology and Biomedical Imaging University of California Box 1667 San Francisco;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    ADC; Apparent diffusion coefficient; Breast cancer; Diffusion-weighted magnetic resonance imaging; DWI; Treatment response;

    机译:ADC;表观扩散系数;乳腺癌;扩散加权磁共振成像;DWI;治疗反应;

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