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首页> 外文期刊>Cutaneous and ocular toxicology >Comparison of the short-term effect of aflibercept and dexamethasone implant on serous retinal detachment in the treatment of naive diabetic macular edema
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Comparison of the short-term effect of aflibercept and dexamethasone implant on serous retinal detachment in the treatment of naive diabetic macular edema

机译：幼虫植入治疗幼稚糖尿病水肿治疗浆膜视网膜脱离的临床近代脱落

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Purpose: The aim of this study is to compare the efficacy of intravitreal injection of aflibercept and dexamethasone implant in the early treatment period of naive diabetic macular edema (DME) with serous retinal detachment (SRD). Materials and methods: In this retrospective comparative study, medical records of patients who received treatment for naive DME with SRD and underwent three monthly intravitreal aflibercept (IVA) injections (2 mg) or one intravitreal dexamethasone implant (IDI) injection (0.7 mg) were reviewed. The best corrected visual acuity (BCVA), central macular thickness (CMT), and presence and height of SRD were compared three months after IDI injection and one month after the third IVA injection. Results: A total of 57 eyes of 49 patients were included in the study. The IVA group consisted of 32 eyes of 27 patients, whereas the IDI group consisted of 25 eyes of 22 patients. Both groups were similar in terms of gender, baseline intraocular pressure, HbA1c levels, types of diabetes, BCVA, CMT, and height of SRD (p = 0.469, p = 0.089, p = 0.889, p = 0.461, p = 0.072, p = 0.073, and p = 0.064, respectively). The mean CMT changes were 228.6 +/- 109.8 mu m and 168.5 +/- 106.4 mu m in the IDI and IVA groups, respectively (p < 0.001 for both groups). The change in CMT was statistically significantly greater in IDI group than in IVA group (p = 0.041). The mean SRD changes were 162.7 +/- 106.9 mu m and 110.7 +/- 51.9 mu m in the IDI and IVA groups, respectively (p < 0.001 for both groups), and the change in SRD height was statistically significantly greater in IDI group than in IVA group (p = 0.019). SRD completely resolved in 92% and 91.2% of the patients in IDI and IVA groups, respectively (p = 0.856). Moreover, BCVA was significantly increased after the injections in both groups (p < 0.001 for both groups), and the change in BCVA was comparable between the groups (p = 0.245). Conclusions: Fewer injections of dexamethasone implant demonstrated better morphological results than aflibercept in the early treatment period of naive diabetic macular edema (DME) with serous retinal detachment (SRD).
机译：目的：本研究的目的是比较含有浆液性视网膜脱离（SRD）的幼稚糖尿病性黄斑（DME）的早期治疗期间AfliBercept和DexameLsone植入术的疗效。材料和方法：在此回顾性比较研究中，接受幼稚DME治疗的患者的病程和患有SRD的患者和接受三次每月术治疗（IVA）注射（2mg）或一个玻璃体内地塞米松植入物（IDI）注射（0.7mg）审查。在IDI注射后三个月和SRD的最佳校正视力（BCVA），中央黄斑厚度（CMT）和存在和高度进行比较，并在第三IVA注射后一个月。结果：研究共有49名患者的57只眼睛。 IVA组由32名患者组成，IDI组包括22名患者25只眼睛。两组在性别，基线眼内压，HBA1C水平，糖尿病类型，BCVA，CMT和SRD高度方面都相似（P = 0.469，P = 0.089，P = 0.889，P = 0.461，P = 0.072，P = 0.073和P = 0.064）。在IDI和IVA组中，平均CMT的变化分别为228.6 +/- 109.8 mu m和168.5 +/-106.4μm（两个组的p <0.001）。在IDI组中，CMT的变化比IVA组在统计学上显着更大（P = 0.041）。 IDI和IVA组的平均SRD变化分别为162.7 +/-106.9μm和110.7 +/- 51.9 mu m比IVA组（P = 0.019）。 SRD分别在IDI和IVA组中的92％和91.2％的患者中完全解决了（P = 0.856）。此外，在两组的注射后，BCVA显着增加（两个基团的P <0.001），并且BCVA的变化在基团之间相当（P = 0.245）。结论：植物的幼稚脱髓鞘（DME）早期治疗期的幼虫（DME）的早期治疗时间较少，较少注射的地塞米松植入物的形态学效果优于AfliBercept。

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