• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >SIS/aligned fibre scaffold designed to meet layered oesophageal tissue complexity and properties
【24h】

SIS/aligned fibre scaffold designed to meet layered oesophageal tissue complexity and properties

机译：SIS /对齐的纤维支架设计，以满足层状食管组织复杂性和性质

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

With donor organs not readily available, the need for a tissue-engineered oesophagus remains high, particularly for congenital childhood conditions such as atresia. Previous attempts have not been successful, and challenges remain. Small intestine submucosa (SIS) is an acellular matrix material with good biological properties; however, as is common with these types of materials, they demonstrate poor mechanical properties. In this work, electrospinning was performed to mechanically reinforce tubular SIS with polylactic-co-glycolic acid (PLGA) nanofibres. It was hypothesised that if attachment could be achieved between the two materials, then this would (i) improve the SIS mechanical properties, (ii) facilitate smooth muscle cell alignment to support directional growth of muscle cells and (iii) allow for the delivery of bioactive molecules (VEGF in this instance).
机译：对于不容易获得的供体器官，需要对组织工程的食道仍然很高，特别是对于atresia等先天性儿童病症。 以前的尝试没有成功，仍然存在挑战。 小肠粘膜（SIS）是一种具有良好生物特性的无细胞基质材料; 然而，与这些类型的材料一样，它们表现出差的机械性能。 在这项工作中，进行静电纺丝以用聚致 - 共乙醇酸（PLGA）纳米纤维机械地加强管状SIS。 假设如果可以在两种材料之间实现附着，那么这将改善SIS机械性能，（ii）促进平滑肌细胞对准以支持肌细胞的方向生长和（iii）允许递送 生物活性分子（在这种情况下VEGF）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号