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首页> 外文期刊>Acta biomaterialia >Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy
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Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy

机译：癌症治疗中超顺磁性氧化铁纳米粒子的靶向策略

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摘要

Among various nanoparticles, superparamagnetic iron oxide nanoparticles (SPIONs) have been increasingly studied for their excellent superparamagnetism, magnetic heating properties, and enhanced magnetic resonance imaging (MRI). The conjugation of SPIONs with drugs to obtain delivery nanosystems has several advantages including magnetic targeted functionalization, in vivo imaging, magnetic thermotherapy, and combined delivery of anticancer agents. To further increase the targeting efficiency of drugs through a delivery nanosystem based on SPIONs, additional targeting moieties including transferrin, antibodies, aptamers, hyaluronic acid, folate, and targeting peptides are coated onto the surface of SPIONs. Therefore, this review summarizes the latest progresses in the conjugation of targeting molecules and drug delivery nanosystems based on SPIONs, especially focusing on their performances to develop efficient targeted drug delivery systems for tumor therapy.
机译：在各种纳米颗粒中，已经越来越多地研究了超顺磁性氧化铁纳米颗粒（散氏），其优异的超顺磁性，磁性加热性能和增强的磁共振成像（MRI）研究。 将散热与药物缀合以获得递送纳米系统的优点包括磁性靶向官能化，体内成像，磁热疗和抗癌剂的组合递送。 为了进一步通过基于酱的递送纳米系统来进一步提高药物的靶向效率，另外的靶向部分包括转铁蛋白，抗体，适体，透明质酸，甲状腺酸，靶向肽涂覆在散氏表面上。 因此，本综述总结了基于酱的靶分子和药物递送纳米系统缀合的最新进展，特别是关注其对肿瘤治疗的有效靶向药物递送系统的性能进行性能。

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